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sx-682

Small moleculeexperimental

Clinical trial activity

11 trials · 21 clinical orgs · 0 marketing orgs

Phase 1
8
Phase 2
7
Phase 3
0
Phase 4
0

Earliest trial started Dec 1, 2017 (NCT03161431)

Timeline

2010s

  1. Jan 1, 2017

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2022

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

O=C(Nc1ccc(F)cc1)c1cnc(SCc2cc(OC(F)(F)F)ccc2B(O)O)nc1
Mol. weight
467.21 g/mol
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • sx-682
  • sx-682

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07002320Phase 1/Phase 2 (Phase 2)Apr 28, 2025Janssen Pharmaceutica NV, Ospedale S. Giovanni Bellinzona, Prostate Cancer UK, Queen's University, Belfast, Royal Marsden Hospital NHS Trust, Syntrix Biosystems, Inc., University of Cambridge, University of London
NCT06622005Phase 1Nov 1, 2024Roswell Park University, State University of New York, Buffalo
NCT06228053Phase 2Jun 5, 2024National Cancer Institute (NCI), Syntrix Biosystems, Inc.
NCT06149481Phase 1/Phase 2 (Phase 2)Jan 3, 2024National Cancer Institute (NCI)
NCT05570825Phase 2Jan 9, 2023National Cancer Institute (NCI), Syntrix Biosystems, Inc., University of Washington
NCT05604560Phase 2Dec 31, 2022BeOne Medicines, Johns Hopkins University, Syntrix Biosystems, Inc.
NCT04574583Phase 1/Phase 2 (Phase 2)Nov 24, 2020National Cancer Institute (NCI)
NCT04477343Phase 1Nov 5, 2020Bristol-Myers Squibb, Syntrix Biosystems, Inc., University of Rochester
NCT04599140Phase 1/Phase 2 (Phase 2)Oct 14, 2020Bristol-Myers Squibb, Syntrix Biosystems, Inc., University of Texas at Houston
NCT04245397Phase 1Feb 29, 2020National Heart, Lung, and Blood Institute (NHLBI), Syntrix Biosystems, Inc., University of South Florida
NCT03161431Phase 1Dec 1, 2017Harvard University, National Cancer Institute (NCI), Syntrix Biosystems, Inc., The Wistar Institute
Showing 11 of 11 trials
Page 1 / 1

Organizations

Research & Development (21)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Syntrix Biosystems, Inc.For profit8322017
National Cancer Institute (NCI)Government5222017
Bristol-Myers SquibbFor profit2022020
BeOne MedicinesFor profit1012022
Harvard UniversityAcademic/Hospital1012017
Janssen Pharmaceutica NVFor profit1012025
Johns Hopkins UniversityAcademic/Hospital1112022
National Heart, Lung, and Blood Institute (NHLBI)Government1012020
Ospedale S. Giovanni BellinzonaAcademic/Hospital1012025
Prostate Cancer UKAcademic/Hospital1012025
Queen's University, BelfastAcademic/Hospital1012025
Roswell Park UniversityAcademic/Hospital1012024
Royal Marsden Hospital NHS TrustAcademic/Hospital1012025
State University of New York, BuffaloAcademic/Hospital1112024
The Wistar InstituteAcademic/Hospital1012017
University of CambridgeAcademic/Hospital1012025
University of LondonAcademic/Hospital1112025
University of RochesterAcademic/Hospital1112020
University of South FloridaAcademic/Hospital1012020
University of Texas at HoustonAcademic/Hospital1112020
21 organizations
Page 1 / 2