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atracurium

Trade name: tracurium

Small moleculeapproved

Approved

Nov 23, 1983

Atracurium is an intermediate-duration, nondepolarizing, skeletal muscle relaxant for intravenous administration. It is used, as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Most adverse reactions were suggestive of histamine release. Common side effects include flushing of the skin and low blood pressure. Drugs which may enhance the neuromuscular blocking action of atracurium include: enflurane; isoflurane; halothane; certain antibiotics, especially the aminoglycosides and polymyxins; lithium; magnesium salts; procainamide; and quinidine. — NCATS

Clinical trial activity

39 trials · 27 clinical orgs · 13 marketing orgs

Phase 1
3
Phase 2
4
Phase 3
3
Phase 4
11

Earliest trial started Jul 1, 2009 (NCT01273831)

Timeline

1980s

  1. Nov 23, 1983

    Hospira — Earliest FDA Approval

  2. Nov 23, 1983

    Hospira — NDA Organization

  3. Nov 23, 1983

    Hospira — NDA Secondary Org

1990s

  1. Jun 11, 1997

    Teva — Marketing Organization

  2. Jul 18, 1997

    West-Ward Pharmaceutical — Marketing Organization

  3. Jul 18, 1997

    Hikma — Marketing Organization

  4. Sep 30, 1997

    Baxalta — Marketing Organization

  5. Sep 30, 1997

    Baxter — Marketing Organization

  6. Jul 28, 1998

    Watson Pharmaceuticals — Marketing Organization

2000s

  1. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Feb 17, 2012

    Eu Yan Sang — Marketing Organization

  2. Feb 17, 2012

    Meitheal — Marketing Organization

  3. Oct 18, 2012

    Hospira — Marketing Organization

  4. Jan 1, 2013

    Earliest Phase 1 Sponsor(trial)

  5. Jan 1, 2015

    Earliest Phase 3 Sponsor(trial)

  6. Apr 8, 2015

    Aurobindo Pharma — Marketing Organization

  7. Apr 8, 2015

    Eugia Pharma — Marketing Organization

  8. Apr 7, 2017

    Mylan — Marketing Organization

  9. Apr 7, 2017

    PHARMOBEDIENT — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedPriority reviewNov 23, 1983

Chemistry & pharmacology

Loading structure…

SMILES

COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]2(C)CCc3cc(OC)c(OC)cc3C2Cc2ccc(OC)c(OC)c2)cc1OC
Mol. weight
929.16 g/mol
Lipinski Ro5
3 violation(s)
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 1-[(3,4-dimethoxyphenyl)methyl]-2-[3-({5-[(3-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propanoyl)oxy]pentyl}oxy)-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium
  • 1-[(3,4-dimethoxyphenyl)methyl]-2-[3-({5-[(3-{1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-2-yl}propanoyl)oxy]pentyl}oxy)-3-oxopropyl]-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium
  • atracurium besilate
  • atracurium besilate
  • atracurium besilate
  • atracurium besylate
  • atracurium besylate
  • atracurium besylate
  • atracurium besylate
  • atracurium besylate
  • atracurium besylate
  • atracurium dibesylate
  • atracurium dibesylate
  • bw-33a
  • bw-33a
  • tracrium
  • tracrium
  • tracrium
  • tracrium
  • tracurium

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07287683Phase 1/Phase 2 (Phase 2)Apr 2, 2025Alexandria University
NCT05706844Phase 4Mar 6, 2023Region Syddanmark, University of Copenhagen
NCT05442905N/AAug 1, 2022Tanta University
NCT05241054N/AMar 31, 2022Mansoura University
NCT05149872Phase 4Jan 31, 2022Leiden University
NCT04945694N/AAug 31, 2021Mansoura University
NCT04922814N/AAug 1, 2021Assiut University
NCT04872192N/AMay 27, 2021Ain Shams University
NCT04614259N/ANov 15, 2020Cairo University
NCT05097508Early Phase 1 (Phase 1)Jun 20, 2020Ain Shams University
NCT04344262N/AMay 1, 2020Mansoura University
NCT04078659N/ASep 30, 2019Mansoura University
NCT04095754N/ASep 30, 2019Ain Shams University
NCT03803267N/AMay 1, 2019Mansoura University
NCT03666949N/AMay 1, 2018University of Caen-Normandie
NCT03426527N/AMar 1, 2018Mansoura University
NCT03371953Phase 4Dec 20, 2017Sir Ganga Ram Hospital
NCT03569046N/ADec 15, 2017Menoufia University
NCT03005860N/AFeb 1, 2017Tata Memorial Hospital
NCT02700893Phase 2/Phase 3 (Phase 3)Mar 1, 2016Centre de Recherche Clinique du CHIC, Centre Hospitalier Intercommunal Creteil
Showing 20 of 39 trials
Page 1 / 2

Organizations

Research & Development (27)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Mansoura UniversityAcademic/Hospital6612018
Ain Shams UniversityAcademic/Hospital3322019
Cairo UniversityAcademic/Hospital3322015
Assiut UniversityAcademic/Hospital2222015
Benazir Bhutto Hospital, RawalpindiAcademic/Hospital2212013
Centre de Recherche Clinique du CHICAcademic/Hospital2012012
Centre Hospitalier Intercommunal CreteilAcademic/Hospital2212012
Leiden UniversityAcademic/Hospital2212012
Mahidol UniversityAcademic/Hospital2222013
Yonsei UniversityAcademic/Hospital2212010
Alexandria UniversityAcademic/Hospital1112025
GZA Ziekenhuizen Campus Sint-AugustinusAcademic/Hospital1112014
Isfahan UniversityAcademic/Hospital1112009
Jiao Tong UniversityAcademic/Hospital1112014
Menoufia UniversityAcademic/Hospital1112017
People's Liberation Army of ChinaGovernment1112015
Region SyddanmarkAcademic/Hospital1012023
Sir Ganga Ram HospitalAcademic/Hospital1112017
St. Antonius Hospital, NieuwegeinAcademic/Hospital1112009
Tanta UniversityAcademic/Hospital1112022
27 organizations
Page 1 / 2

Marketing (17)

OrganizationOrg typeRelationshipDate
Aurobindo PharmaFor profitMKTGApr 8, 2015
BaxaltaFor profitSYNJan 23, 1997
BaxaltaFor profitMKTGSep 30, 1997
BaxterFor profitMKTGSep 30, 1997
Eu Yan SangFor profitMKTGFeb 17, 2012
Eugia PharmaFor profitMKTGApr 8, 2015
HikmaFor profitMKTGJul 18, 1997
HospiraFor profitNDANov 23, 1983
HospiraFor profitNDA2Nov 23, 1983
HospiraFor profitMKTGOct 18, 2012
MeithealFor profitMKTGFeb 17, 2012
MylanFor profitMKTGApr 7, 2017
PHARMOBEDIENTFor profitMKTGApr 7, 2017
TevaFor profitMKTGJun 11, 1997
Watson PharmaceuticalsFor profitMKTGJul 28, 1998
Watson PharmaceuticalsFor profitSYNJul 28, 1998
West-Ward PharmaceuticalFor profitMKTGJul 18, 1997