kpt-330
Small moleculeexperimental
Clinical trial activity
7 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
7
Phase 3
0
Phase 4
0
Earliest trial started Sep 1, 2017 (NCT03193437)
Timeline
Indications
Mechanism of action
- Exportin-1INHIBITOR
XPO1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(/C=C\n1cnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)n1)NNc1cnccn1- Mol. weight
- 443.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
First in class
Sources
- ChEMBLCHEMBL3545185 ↗
Also known as
- kpt-330
- kpt-330
- open label selinexor
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06822972 | Phase 2 | May 1, 2025 | Duke University |
| NCT05980806 | Phase 2 | Mar 31, 2024 | Karyopharm Therapeutics Inc |
| NCT05975944 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2023 | Tianjin Medical University |
| NCT06114004 | Phase 2 | Sep 28, 2023 | Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas, Universidad Autonoma de Madrid |
| NCT05850286 | Phase 2 | Apr 20, 2023 | China Academy of Chinese Medical Sciences |
| NCT05974085 | Phase 2 | Aug 1, 2022 | Chinese Academy of Medical Sciences |
| NCT03193437 | Phase 2 | Sep 1, 2017 | Georgetown University, Karyopharm Therapeutics Inc, Rutgers University |
Showing 7 of 7 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Karyopharm Therapeutics Inc | For profit | 2 | 1 | 1 | 2017 |
| Asociación Europea y Latinoamericana SELNET para la Investigación en Sarcomas | Academic/Hospital | 1 | 1 | 1 | 2023 |
| China Academy of Chinese Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Georgetown University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Rutgers University | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Tianjin Medical University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Universidad Autonoma de Madrid | Academic/Hospital | 1 | 0 | 1 | 2023 |
9 organizations
Page 1 / 1