mva-bn

Trade name: JYNNEOS

Vaccineapproved

Approved

Sep 24, 2019

The smallpox vaccine is used to prevent smallpox infection caused by the variola virus. It is the first vaccine to have been developed against a contagious disease. In 1796, British physician Edward Jenner demonstrated that an infection with the relatively mild cowpox virus conferred immunity against the deadly smallpox virus. Cowpox served as a natural vaccine until the modern smallpox vaccine emerged in the 20th century. From 1958 to 1977, the World Health Organization (WHO) conducted a global vaccination campaign that eradicated smallpox, making it the only human disease to be eradicated. Although routine smallpox vaccination is no longer performed on the general public, the vaccine is still being produced for research, and to guard against bioterrorism, biological warfare, and mpox. — Wikipedia

Clinical trial activity

22 trials · 25 clinical orgs · 1 marketing orgs

Phase 1
6
Phase 2
14
Phase 3
4
Phase 4
1

Earliest trial started Nov 2, 1999 (NCT00002261)

Timeline

1990s

  1. Jan 1, 1999

    Earliest Phase 1 Sponsor(trial)

2000s

  1. Jan 1, 2002

    Earliest Phase 2 Sponsor(trial)

2010s

  1. Jan 1, 2015

    Bavarian Nordic — Earliest Phase 3 Sponsor(trial)

  2. Sep 24, 2019

    Bavarian Nordic — Earliest FDA Approval

  3. Sep 24, 2019

    Bavarian Nordic — NDA Secondary Org

  4. Sep 24, 2019

    Bavarian Nordic — NDA Organization

Indications

Mechanism of action

  • Unspecified targetOTHER

    Biological vaccine - induces immune response

  • Cowpox virusImmunity, active

    Cowpox virus immunity, active

Approval history

  • approvedSep 24, 2019

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • modified vaccinia ankara - bavarian nordic (mva-bn) virus
  • mva-b
  • mva bn
  • mva-bn
  • smallpox vaccine
  • smallpox vaccine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07253675Phase 2Dec 31, 2025China National Biotec Group Co., Ltd, University of Kinshasa
NCT07199569Phase 2Oct 27, 2025Bavarian Nordic, ICON
NCT06839989Phase 2Aug 4, 2025Institute of Tropical Medicine, Belgium
NCT06844500Phase 3Jun 23, 2025ace africa, Bavarian Nordic, European and Developing Countries Clinical Trials Partnership (EDCTP), PENTA Foundation, University of Antwerp, University of Kinshasa
NCT06844487Phase 3May 29, 2025ace africa, Bavarian Nordic, European and Developing Countries Clinical Trials Partnership (EDCTP), PENTA Foundation, University of Antwerp, University of Kinshasa
NCT06549530Phase 2Oct 16, 2024Bavarian Nordic, Coalition for Epidemic Preparedness Innovations
NCT06366672Early Phase 1 (Phase 1)Jun 10, 2024Washington University in St. Louis
NCT05734508Phase 4Mar 23, 2023Government of Congo, National Institute of Allergy and Infectious Diseases (NIAID)
NCT05740982Phase 2Mar 22, 2023National Institute of Allergy and Infectious Diseases (NIAID)
NCT05512949Phase 2Sep 7, 2022National Institute of Allergy and Infectious Diseases (NIAID)
NCT05438953N/AJul 12, 2022Assistance Publique - Hôpitaux de Paris
NCT04957485Phase 2Oct 21, 2021Department of Defense, Medical CBRN Defense Consortium (MCDC), SIGA Technologies
NCT03699124Phase 3Apr 1, 2019Bavarian Nordic, Department of Health and Human Services, University of Alabama, Birmingham
NCT01913353Phase 3Mar 1, 2015Bavarian Nordic, United States Army
NCT00565929Phase 1Sep 1, 2008National Institute of Allergy and Infectious Diseases (NIAID)
NCT00679497Phase 1Jun 1, 2008University of Barcelona
NCT00316602Phase 2Jul 1, 2006Bavarian Nordic, National Institute of Allergy and Infectious Diseases (NIAID), University of Kentucky
NCT00316524Phase 2May 1, 2006Bavarian Nordic, Ludwig Maximilians University, National Institute of Allergy and Infectious Diseases (NIAID)
NCT00050518Phase 2Dec 11, 2002National Institute of Allergy and Infectious Diseases (NIAID)
NCT00189943Phase 1Apr 1, 2001Bavarian Nordic, PharmPlanNet Contract Research GmbH
Showing 20 of 22 trials
Page 1 / 2

Organizations

Research & Development (25)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Bavarian NordicFor profit9732001
National Institute of Allergy and Infectious Diseases (NIAID)Government8631999
University of KinshasaAcademic/Hospital3022025
ace africaAcademic/Hospital2012025
European and Developing Countries Clinical Trials Partnership (EDCTP)Academic/Hospital2012025
PENTA FoundationAcademic/Hospital2012025
University of AntwerpAcademic/Hospital2212025
Assistance Publique - Hôpitaux de ParisAcademic/Hospital1112022
Bristol-Myers SquibbFor profit1111999
China National Biotec Group Co., LtdFor profit1112025
Coalition for Epidemic Preparedness InnovationsAcademic/Hospital1012024
Department of DefenseGovernment1012021
Department of Health and Human ServicesGovernment1012019
Government of CongoGovernment1012023
ICONFor profit1012025
Institute of Tropical Medicine, BelgiumAcademic/Hospital1112025
Ludwig Maximilians UniversityAcademic/Hospital1012006
Medical CBRN Defense Consortium (MCDC)Academic/Hospital1012021
PharmPlanNet Contract Research GmbHFor profit1012001
SIGA TechnologiesFor profit1112021
25 organizations
Page 1 / 2

Marketing (2)

OrganizationOrg typeRelationshipDate
Bavarian NordicFor profitNDA2Sep 24, 2019
Bavarian NordicFor profitNDASep 24, 2019