escherichia coli nissle 1917
Cell therapyexperimental
Clinical trial activity
15 trials · 25 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
3
Phase 4
5
Earliest trial started Feb 1, 2009 (NCT01013259)
Timeline
Indications
Approved for
Studied for
- Colitis, Ulcerative · Phase 4
- Colorectal Neoplasms · Phase 3
- Conjunctivitis · Phase 2
- Constipation · Phase 4
- Diabetes Mellitus · Phase 1
- Diabetes Mellitus, Type 2 · Phase 3
- Diarrhea, Infantile · Phase 4
- Infections · Phase 3
- Patient Compliance · Phase 2
- Secondary Prevention · Phase 4
- Stomach Neoplasms · Phase 3
- Urinary Tract Infections · Phase 4
Mechanism of action
- microbiotaTissue restoration
microbiota tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- e. coli nissle
- e. coli nissle 1917
- e. coli strain nissle 1917
- escherichia coli nissle 1917
- probiotic
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05816577 | Phase 1 | Jun 1, 2023 | University of Amsterdam |
| NCT04608851 | Phase 4 | Dec 1, 2020 | Kuopio University Hospital, University of Helsinki, University of Oulu, University of Tampere, University of Turku |
| NCT03800147 | N/A | Jan 24, 2019 | University of Zurich |
| NCT04969679 | Phase 4 | Mar 16, 2018 | Kangbuk Samsung Hospital |
| NCT04787276 | N/A | Jan 10, 2017 | Bogomolets National Medical University |
| NCT02726295 | Phase 4 | Sep 1, 2016 | Dankook University, Keimyung University |
| NCT02953171 | N/A | Sep 1, 2016 | University of Copenhagen |
| NCT02802059 | Phase 3 | Oct 1, 2015 | Ardeypharm GmbH, ICON |
| NCT02706184 | Phase 3 | Jul 1, 2015 | Ardeypharm GmbH, University of Hohenheim, ZKES GmbH |
| NCT02276508 | Phase 1 | Oct 1, 2014 | Ohio State University |
| NCT02144948 | Phase 3 | Aug 1, 2014 | Ardeypharm GmbH, GWT-TUD GmbH, Technical University of Dresden |
| NCT01469273 | Phase 4 | Nov 1, 2011 | Hospital San Bartolome, Instituto de Investigacion de las Alteraciones del Crecimiento, Desarrollo y Enfermedades Metabolicas |
| NCT01320358 | Phase 2 | May 10, 2011 | IQVIA, Novartis, Proteus Digital Health, Inc. |
| NCT01772615 | Phase 4 | May 1, 2011 | University of Copenhagen |
| NCT01013259 | Phase 2 | Feb 1, 2009 | Humboldt University |
Showing 15 of 15 trials
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Organizations
Research & Development (25)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ardeypharm GmbH | For profit | 3 | 1 | 1 | 2014 |
| University of Copenhagen | Academic/Hospital | 2 | 2 | 2 | 2011 |
| Bogomolets National Medical University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Dankook University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| GWT-TUD GmbH | For profit | 1 | 1 | 1 | 2014 |
| Hospital San Bartolome | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Humboldt University | Academic/Hospital | 1 | 1 | 1 | 2009 |
| ICON | For profit | 1 | 0 | 1 | 2015 |
| Instituto de Investigacion de las Alteraciones del Crecimiento, Desarrollo y Enfermedades Metabolicas | Academic/Hospital | 1 | 0 | 1 | 2011 |
| IQVIA | For profit | 1 | 0 | 1 | 2011 |
| Kangbuk Samsung Hospital | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Keimyung University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Kuopio University Hospital | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Novartis | For profit | 1 | 1 | 1 | 2011 |
| Ohio State University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Proteus Digital Health, Inc. | For profit | 1 | 0 | 1 | 2011 |
| Technical University of Dresden | Academic/Hospital | 1 | 0 | 1 | 2014 |
| University of Amsterdam | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Helsinki | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University of Hohenheim | Academic/Hospital | 1 | 1 | 1 | 2015 |
25 organizations
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