hydroxypropyl cellulose
Trade name: Lacrisert
Approved
Jun 1, 1981
Hydroxypropyl cellulose (HPC) is a derivative of cellulose with both water solubility and organic solubility. It is used as an excipient; a topical ophthalmic protectant and lubricant; a thickener, emulsifier, and stabilizer in cosmetic formulations; a sieving matrix for DNA separations by capillary and microchip electrophoresis; a leather consolidant used in book preservation; and a wood consolidant. — Wikipedia
Clinical trial activity
1 trials · 1 clinical orgs · 3 marketing orgs
Earliest trial started Nov 1, 2016 (NCT03079271)
Timeline
1980s
- Jun 1, 1981
Earliest FDA Approval
- Jun 1, 1981
Bausch Health Companies — NDA Secondary Org
- Jun 1, 1981
Bausch & Lomb — Marketing Organization
- Jun 1, 1981
Bausch & Lomb — NDA Secondary Org
Indications
Approved for
Studied for
Mechanism of action
- UnclearUnclear
Unclear unclear
Approval history
- approvedJun 1, 1981
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Discontinued
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaHydroxypropyl cellulose ↗
- NCATS9XZ8H6N6OH ↗
- ChEMBLCHEMBL1201471 ↗
Also known as
- cellulose, 2-hydroxypropyl ether
- cellulose hydroxypropyl ether
- cellulose hydroxypropyl ether
- cellulose hydroxypropyl ether
- e463
- e463
- hiprolosa
- hydroxypropylcellulose
- hydroxypropylcellulose
- hydroxypropylcellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose
- hydroxypropyl cellulose (type h)
- hydroxypropyl cellulose (type h)
- hydroxypropyl cellulose (type h)
- hydroxypropyl cellulose, unspecified
- hyprolose
- hyprolose
- hyprolose
- hyprolosum
- lacrisert
- lacrisert
- lacrisert
- lacrisert
- lacrisert
- low-substituted hydroxypropylcellulose
- modified cellulose
- zilactin
- zilactin b
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03079271 | Phase 4 | Nov 1, 2016 | Virginia Eye Consultants |
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Virginia Eye Consultants | Academic/Hospital | 1 | 1 | 1 | 2016 |
Marketing (4)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Aton | For profit | NDA | — |
| Bausch & Lomb | For profit | MKTG | Jun 1, 1981 |
| Bausch & Lomb | For profit | NDA2 | Jun 1, 1981 |
| Bausch Health Companies | For profit | NDA2 | Jun 1, 1981 |