l-isoleucine
Small moleculeexperimental
Isoleucine is an essential α-amino acid that is used in the biosynthesis of proteins. L-isoleucine is commonly used in parenteral and enteral nutrition. It is used in combination with the other branched chain amino acids to improve the nutritional status of patients with hepatic diseases. BCAAs serve as important fuel sources for skeletal muscle during periods of metabolic stress — NCATS
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
1
Earliest trial started Apr 1, 2007 (NCT01434524)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Mechanism of action
- Isoleucyl-tRNA synthetaseSUBSTRATE
IARS1 substrate
Chemistry & pharmacology
Loading structure…
SMILES
CC[C@H](C)[C@H](N)C(O)=O- Mol. weight
- 131.1729 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIsoleucine ↗
- NCATS04Y7590D77 ↗
- ChEMBLCHEMBL1233584 ↗
Also known as
- 2-amino-3-methylvaleric acid
- 2-amino-3-methylvaleric acid
- (2s,3s)-2-amino-3-methylpentanoic acid
- (2s,3s)-2-amino-3-methylpentanoic acid
- alpha-amino-beta-methylvaleric acid
- alpha-amino-beta-methylvaleric acid
- i
- i
- ile
- ile
- isoleucine
- isoleucine
- isoleucine
- isoleucine
- isoleucine
- isoleucine
- isoleucine
- isoleucine
- l-isoleucine
- l-isoleucine
- l-isoleucine
- l-isoleucine
- α-amino-β-methylvaleric acid
- α-amino-β-methylvaleric acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05682339 | N/A | Jun 19, 2023 | University of Adelaide |
| NCT03180775 | N/A | Jul 1, 2017 | Technion University |
| NCT02634164 | N/A | Dec 1, 2015 | Texas Woman's University |
| NCT02837302 | Phase 4 | Nov 1, 2012 | Kyungpook University, Samil Pharmaceutical Co., Ltd. |
| NCT01434524 | N/A | Apr 1, 2007 | Kochi University |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Kochi University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Kyungpook University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Samil Pharmaceutical Co., Ltd. | For profit | 1 | 0 | 1 | 2012 |
| Technion University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Texas Woman's University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Adelaide | Academic/Hospital | 1 | 1 | 1 | 2023 |
6 organizations
Page 1 / 1