danegaptide
Peptideexperimental
Clinical trial activity
11 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
5
Phase 3
1
Phase 4
0
Earliest trial started Sep 1, 2007 (NCT00510029)
Timeline
Indications
Mechanism of action
- Gap junction alpha-1 proteinINHIBITOR
GJA1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
NCC(=O)N1C[C@H](NC(=O)c2ccccc2)C[C@H]1C(=O)O- Mol. weight
- 291.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL560592 ↗
Also known as
- 1-(2-aminoacetyl)-4-benzamidopyrrolidine-2-carboxylic acid
- danegaptide
- danegaptide
- danegaptide
- danegaptide
- gap 134
- gap-134
- gap-134
- gap-134
- gap-134
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02012387 | Phase 2 | Jan 1, 2014 | Clinica Universidad de Navarra, Hospital General Universitario Gregorio Marañon, Hospital Joan XXIII de Tarragona, Tarragona, Spain, Hospital Universitario Central de Asturias, Universidad Autonoma de Barcelona, University of Barcelona |
| NCT01977755 | Phase 2 | Nov 1, 2013 | University of Copenhagen, Zealand Pharma |
| NCT01316315 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2011 | Duke University, Nivalis Therapeutics, Inc., University of Colorado, Denver |
| NCT01366560 | Phase 1 | Aug 1, 2010 | GlaxoSmithKline |
| NCT01119313 | Phase 2 | Feb 1, 2010 | Almirall |
| NCT01051232 | Phase 1 | Feb 1, 2010 | Pfizer |
| NCT01389518 | Phase 3 | May 1, 2009 | Federal University of Rio Grande do Sul |
| NCT00820521 | Phase 1 | Feb 1, 2009 | Pfizer, Wyeth |
| NCT00783341 | Phase 1 | Nov 1, 2008 | Pfizer, Wyeth |
| NCT00543946 | Phase 1 | Oct 1, 2007 | Pfizer, Wyeth |
| NCT00510029 | Phase 1 | Sep 1, 2007 | Pfizer, Wyeth |
Showing 11 of 11 trials
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Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 5 | 5 | 1 | 2007 |
| Wyeth | For profit | 4 | 0 | 1 | 2007 |
| Almirall | For profit | 1 | 1 | 1 | 2010 |
| Clinica Universidad de Navarra | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Duke University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Federal University of Rio Grande do Sul | Academic/Hospital | 1 | 1 | 1 | 2009 |
| GlaxoSmithKline | For profit | 1 | 1 | 1 | 2010 |
| Hospital General Universitario Gregorio Marañon | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Hospital Joan XXIII de Tarragona, Tarragona, Spain | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Hospital Universitario Central de Asturias | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Nivalis Therapeutics, Inc. | For profit | 1 | 1 | 1 | 2011 |
| Universidad Autonoma de Barcelona | Academic/Hospital | 1 | 0 | 1 | 2014 |
| University of Barcelona | Academic/Hospital | 1 | 0 | 1 | 2014 |
| University of Colorado, Denver | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Zealand Pharma | For profit | 1 | 1 | 1 | 2013 |
16 organizations
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