cx 5461
Small moleculeexperimental
Clinical trial activity
7 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started May 16, 2016 (NCT02719977)
Timeline
2010s
- Jan 1, 2016
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
POLR1A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cnc(CNC(=O)c2c(=O)c3ccc(N4CCCN(C)CC4)nc3n3c2sc2ccccc23)cn1- Mol. weight
- 513.63 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4303309 ↗
Also known as
- cx5461
- cx5461
- cx5461
- cx 5461
- cx-5461
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07069699 | Phase 1/Phase 2 (Phase 2) | Dec 31, 2025 | National Cancer Institute (NCI), Yale University |
| NCT07147231 | Phase 1/Phase 2 (Phase 2) | Dec 31, 2025 | Johns Hopkins University, National Cancer Institute (NCI) |
| NCT07137416 | Phase 1 | Dec 9, 2025 | Harvard University, National Cancer Institute (NCI) |
| NCT06606990 | Phase 1 | Dec 16, 2024 | National Cancer Institute (NCI), National Institutes of Health (NIH) |
| NCT05425862 | Phase 1 | Oct 21, 2022 | Peter MacCallum Cancer Centre |
| NCT04890613 | Phase 1 | Sep 8, 2021 | Senhwa Biosciences, Inc. |
| NCT02719977 | Phase 1/Phase 2 (Phase 2) | May 16, 2016 | British Columbia Cancer Agency, Canadian Cancer Trials Group, Senhwa Biosciences, Inc., Stand Up To Cancer, University of Ottawa |
Showing 7 of 7 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 4 | 4 | 2 | 2024 |
| Senhwa Biosciences, Inc. | For profit | 2 | 1 | 2 | 2016 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Canadian Cancer Trials Group | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2024 |
| Peter MacCallum Cancer Centre | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Stand Up To Cancer | Academic/Hospital | 1 | 0 | 1 | 2016 |
| University of Ottawa | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Yale University | Academic/Hospital | 1 | 0 | 1 | 2025 |
11 organizations
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