huperzine a
Small moleculeexperimental
Clinical trial activity
13 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
4
Phase 3
1
Phase 4
2
Earliest trial started May 15, 2017 (NCT03101722)
Timeline
Indications
Approved for
Mechanism of action
- AcetylcholinesteraseINHIBITOR
Acetylcholinesterase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C/C=C1\[C@H]2C=C(C)C[C@@]1(N)c1ccc(=O)[nH]c1C2- Mol. weight
- 242.32 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL395280 ↗
- ChEMBLCHEMBL1255901 ↗
Also known as
- bis-001
- huperzine a
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07066826 | Phase 2/Phase 3 (Phase 3) | Aug 1, 2025 | WanBangDe Pharmaceutical Group Co.,Ltd. |
| NCT07141329 | Phase 2 | Jul 30, 2025 | Supernus Pharmaceuticals |
| NCT06798896 | Phase 2 | Dec 30, 2024 | Supernus Pharmaceuticals |
| NCT06570655 | Phase 1 | May 16, 2024 | WanBangDe Pharmaceutical Group Co.,Ltd., Zhejiang University |
| NCT05560373 | Phase 4 | Sep 30, 2022 | WanBangDe Pharmaceutical Group Co.,Ltd., Zhejiang University |
| NCT05518578 | Phase 2 | Sep 30, 2022 | Supernus Pharmaceuticals |
| NCT05242419 | N/A | Feb 20, 2022 | Wenzhou Medical University |
| NCT05102552 | Early Phase 1 (Phase 1) | Oct 19, 2021 | Supernus Pharmaceuticals |
| NCT04509323 | Phase 4 | Aug 3, 2020 | Guangzhou Pharmaceucal Company Limited |
| NCT03474770 | Phase 1/Phase 2 (Phase 2) | Apr 2, 2018 | Biscayne Neurotherapeutics, Inc. |
| NCT03445104 | Early Phase 1 (Phase 1) | Jan 16, 2018 | St. Louis University |
| NCT03156439 | Phase 1 | May 22, 2017 | Biscayne Neurotherapeutics, Inc., Melbourne Health |
| NCT03101722 | N/A | May 15, 2017 | Fudan University |
Showing 13 of 13 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Supernus Pharmaceuticals | For profit | 4 | 4 | 2 | 2021 |
| WanBangDe Pharmaceutical Group Co.,Ltd. | For profit | 3 | 3 | 3 | 2022 |
| Biscayne Neurotherapeutics, Inc. | For profit | 2 | 2 | 2 | 2017 |
| Zhejiang University | Academic/Hospital | 2 | 0 | 2 | 2022 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Guangzhou Pharmaceucal Company Limited | For profit | 1 | 1 | 1 | 2020 |
| Melbourne Health | Academic/Hospital | 1 | 0 | 1 | 2017 |
| St. Louis University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Wenzhou Medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
9 organizations
Page 1 / 1