amniotic epithelial cells
An amniotic epithelial cell is a form of stem cell extracted from the lining of the inner membrane of the placenta. Amniotic epithelial cells start to develop around 8 days post fertilization. These cells are known to have some of the same markers as embryonic stem cells, more specifically, Oct-4 and nanog. These transcription factors are the basis of the pluripotency of stem cells. Amniotic epithelial cells have the ability to develop into any of the three germ layers: endoderm, mesoderm, and ectoderm. They can develop into several organ tissues specific to these germ layers including heart, brain, and liver. The pluripotency of the human amniotic epithelial cells makes them useful in treating and fighting diseases and disorders of the nervous system as well as other tissues of the human body. Artificial heart valves and working tracheas, as well as muscle, fat, bone, heart, neural and liver cells have all been engineered using amniotic stem cells. Tissues obtained from amniotic cell lines show promise for patients with congenital diseases or malformations of the heart, liver, lungs, kidneys, and cerebral tissue. — Wikipedia
Clinical trial activity
15 trials · 11 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2014 (NCT02344329)
Timeline
2010s
- Jan 1, 2016
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Studied for
- Bronchial Fistula · Phase 1
- Cerebral Palsy · Phase 1
- Diabetes Mellitus · Phase 4
- Diabetic Foot · Phase 4
- Fractures, Bone · Phase 1/Phase 2
- Graft vs Host Disease · Phase 1
- Gynatresia · Phase 1
- Infertility · Phase 1
- Parkinson Disease · Phase 1
- Primary Ovarian Insufficiency · Phase 1
- Tissue Adhesions · Early Phase 1
Mechanism of action
- Unspecified targetTissue restoration
tissue restoration
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAmniotic epithelial cell ↗
Also known as
- amniotic epithelial cells
- human amniotic epithelial cells
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06444022 | Early Phase 1 (Phase 1) | Jul 31, 2024 | Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China, Southern Medical University |
| NCT06164288 | Phase 1 | Jan 1, 2024 | Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT05691114 | Phase 1 | Feb 28, 2023 | Huazhong University of Science and Technology, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT05435755 | Early Phase 1 (Phase 1) | Dec 2, 2022 | Huazhong University of Science and Technology, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT04414813 | Early Phase 1 (Phase 1) | Jun 30, 2020 | Huazhong University of Science and Technology, Shanghai East Hospital . China, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT03764228 | N/A | Dec 1, 2018 | Peking University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT03381807 | Early Phase 1 (Phase 1) | Mar 1, 2018 | Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China, Zhejiang University |
| NCT03207412 | N/A | Dec 22, 2017 | Chongqing Medical University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT03031509 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2017 | Huazhong University of Science and Technology, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT03223454 | Phase 1 | Oct 31, 2017 | Chongqing Medical University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT03107975 | Phase 1 | Apr 1, 2017 | Fujian Medical University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT02959333 | Phase 1 | Oct 1, 2016 | Fujian Medical University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT02912104 | Phase 1 | Sep 1, 2016 | Jiao Tong University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China, The International Peace Maternity & Child Health Hospital of China welfare institute |
| NCT02961712 | Phase 1 | Jul 1, 2016 | Fujian Medical University, Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China |
| NCT02344329 | Phase 4 | Aug 1, 2014 | University of North Dakota |
Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China | For profit | 14 | 1 | 3 | 2016 |
| Huazhong University of Science and Technology | Academic/Hospital | 4 | 4 | 2 | 2017 |
| Fujian Medical University | Academic/Hospital | 3 | 3 | 1 | 2016 |
| Chongqing Medical University | Academic/Hospital | 2 | 2 | 2 | 2017 |
| Jiao Tong University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Peking University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Shanghai East Hospital . China | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Southern Medical University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| The International Peace Maternity & Child Health Hospital of China welfare institute | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of North Dakota | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2018 |