y90 anti-cd45 monoclonal antibody bc8
mAbexperimentalADC
Clinical trial activity
6 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2012 (NCT01300572)
Timeline
2010s
- Jan 1, 2012
Earliest Phase 1 Sponsor(trial)
Indications
Studied for
- Anemia, Refractory · Phase 1
- Burkitt Lymphoma · Phase 1
- Hodgkin Disease · Phase 1/Phase 2
- Intraocular Lymphoma · Phase 1
- Leukemia · Phase 1/Phase 2
- Leukemia, Hairy Cell · Phase 1
- Leukemia, Large Granular Lymphocytic · Phase 1
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 1
- Leukemia-Lymphoma, Adult T-Cell · Phase 1
- Leukemia, Myeloid, Acute · Phase 1/Phase 2
- Leukemia, Myelomonocytic, Chronic · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Lymphoma, B-Cell, Marginal Zone · Phase 1
- Lymphoma, Follicular · Phase 1
- Lymphoma, Large-Cell, Anaplastic · Phase 1
- Lymphoma, Large-Cell, Immunoblastic · Phase 1
- Lymphoma, Mantle-Cell · Phase 1/Phase 2
- Lymphoma, Non-Hodgkin · Phase 1/Phase 2
- Lymphoma, T-Cell · Phase 1
- Lymphoma, T-Cell, Peripheral · Phase 1
- Lymphomatoid Granulomatosis · Phase 1
- Multiple Myeloma · Phase 1
- Myelodysplastic Syndromes · Phase 1/Phase 2
- Neoplasms · Phase 1/Phase 2
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma · Phase 1/Phase 2
- Sezary Syndrome · Phase 1
- Testicular Neoplasms · Phase 1
- Waldenstrom Macroglobulinemia · Phase 1
Mechanism of action
- Leukocyte common antigenINHIBITOR
PTPRC inhibitor
Chemistry & pharmacology
- Multi-specific
- No
- Payload
- 90-Yttrium
Oral
No
Parenteral
No
Topical
No
Also known as
- y90 anti-cd45 monoclonal antibody bc8
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04083183 | Phase 1/Phase 2 (Phase 2) | Sep 30, 2019 | National Heart, Lung, and Blood Institute (NHLBI), University of Washington |
| NCT03670966 | Phase 1/Phase 2 (Phase 2) | Nov 12, 2018 | National Cancer Institute (NCI), University of Washington |
| NCT01921387 | Phase 1/Phase 2 (Phase 2) | Oct 1, 2013 | National Cancer Institute (NCI), University of Washington |
| NCT01678443 | Phase 1 | Dec 1, 2012 | National Cancer Institute (NCI), University of Washington |
| NCT01503242 | Phase 1 | Jan 9, 2012 | National Cancer Institute (NCI), University of Washington |
| NCT01300572 | Phase 1 | Jan 1, 2012 | National Cancer Institute (NCI), University of Washington |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Washington | Academic/Hospital | 6 | 6 | 2 | 2012 |
| National Cancer Institute (NCI) | Government | 5 | 0 | 2 | 2012 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2019 |
3 organizations
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