volinanserin
Small moleculeexperimental
Volinanserin is a highly selective 5-HT2A receptor antagonist that is frequently used in scientific research to investigate the function of the 5-HT2A receptor. It was also tested in clinical trials as a potential antipsychotic, antidepressant, and treatment for insomnia but was never marketed. — Wikipedia
Clinical trial activity
5 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
5
Phase 3
4
Phase 4
0
Earliest trial started Sep 1, 2003 (NCT00070694)
Timeline
Indications
Mechanism of action
- Serotonin 2a (5-HT2a) receptorANTAGONIST
HTR2A antagonist
Chemistry & pharmacology
Loading structure…
SMILES
COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC- Mol. weight
- 373.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaVolinanserin ↗
- ChEMBLCHEMBL74355 ↗
Also known as
- 4-piperidinemethanol, alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenyl)ethyl)-, (alpha-r)-
- alpha-(2,3-dimethoxyphenyl)-1-(2-(4-fluorophenylethyl))-4-piperidine methanol
- m100907
- m-100907
- m-100907
- mdl100105
- mdl 100105
- mdl 100907
- mdl 100,907
- mdl-100907
- mdl-100907
- mdl-100907
- mdl-100,907
- mdl-100.907
- mdl-100.907
- mdl100.907
- mdl100.907
- (r)-(2,3-dimethoxyphenyl)(1-(2-(4-fluorophenyl)ethyl)piperidin-4-yl)methanol
- volinanserin
- volinanserin
- volinanserin
- volinanserin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00788515 | Phase 3 | Nov 1, 2008 | Sanofi |
| NCT00495885 | Phase 3 | Jun 1, 2007 | Sanofi |
| NCT00464061 | Phase 3 | Apr 1, 2007 | Sanofi |
| NCT00464243 | Phase 3 | Apr 1, 2007 | Sanofi |
| NCT00070694 | Phase 2 | Sep 1, 2003 | National Institute of Mental Health (NIMH) |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sanofi | For profit | 4 | 4 | 1 | 2007 |
| National Institute of Mental Health (NIMH) | Government | 1 | 1 | 1 | 2003 |
2 organizations
Page 1 / 1