voglibose
Voglibose is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diabetes mellitus. Voglibose is a research product of Takeda Pharmaceutical Company, Japan's largest pharmaceutical company. Voglibose was discovered in 1981, and was first launched in Japan in 1994, under the trade name BASEN, to improve postprandial hyperglycemia in diabetes mellitus. — Wikipedia
Clinical trial activity
18 trials · 16 clinical orgs · 0 marketing orgs
Earliest trial started Apr 1, 2005 (NCT00212017)
Timeline
Indications
Approved for
Mechanism of action
- Alpha glucosidaseINHIBITOR
Alpha glucosidase inhibitor
Voglibose inhibits, in a competitive way, maltase and sucrase enzymes (alpha-glucosidases) in the small intestine (IC50=0.015uM for maltase enzymes and 0.0046uM for sucrase enzymes). This prevents the breakdown of larger carbohydrates into glucose and decreases the rise in postprandial blood glucose levels.
Chemistry & pharmacology
SMILES
OCC(CO)N[C@H]1C[C@](O)(CO)[C@@H](O)[C@H](O)[C@H]1O- Mol. weight
- 267.28 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaVoglibose ↗
- ChEMBLCHEMBL476960 ↗
Also known as
- 3,4-dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-c-(hydroxymethyl)-d-epi-inositol
- a-71100
- a-71100
- ao 128
- ao-128
- ao-128
- ao-128
- ao-128
- basen
- basen
- basen
- basen
- epi-inositol, 2,3-dideoxy-2-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-4-c-(hydroxymethyl)-
- glustat
- glustat
- glustat
- n-(1,3-dihydroxy-2-propyl)valiolamine
- voglibose
- voglibose
- voglibose
- voglibose
- voglibose
- voglibose
- voglibose
- voglibose
- voglibose
- voglistat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05688332 | Phase 3 | Aug 31, 2023 | University of Zambia, University Teaching Hospital, Lusaka, Zambia |
| NCT02954692 | Phase 4 | Nov 30, 2016 | Sanofi |
| NCT02730377 | Phase 4 | Mar 28, 2016 | Novo Nordisk |
| NCT02049814 | Phase 4 | Jun 1, 2014 | Takeda |
| NCT02097342 | Phase 4 | Dec 1, 2013 | Postgraduate Institute of Medical Education and Research |
| NCT01309698 | Phase 4 | Feb 1, 2011 | Novartis |
| NCT02287402 | Phase 4 | Mar 1, 2010 | Takeda |
| NCT00970528 | Phase 4 | Nov 1, 2009 | Bayer |
| NCT00837577 | Phase 3 | Feb 5, 2009 | Merck |
| NCT00724542 | N/A | Jul 1, 2008 | Government of China, Peking University, Takeda |
| NCT00654381 | Phase 3 | Apr 1, 2008 | Boehringer Ingelheim |
| NCT00663884 | Phase 4 | Feb 1, 2008 | Catholic University of Korea, JW Pharmaceutical |
| NCT01263509 | Phase 2/Phase 3 (Phase 3) | Jun 1, 2007 | Kawasaki Medical University, Takeda |
| NCT01263496 | Phase 2 | May 1, 2007 | Kawasaki Medical University, Takeda |
| NCT01263483 | Phase 2/Phase 3 (Phase 3) | Jan 1, 2007 | Kawasaki Medical University, Takeda |
| NCT01263470 | Phase 2 | Jan 1, 2007 | Kawasaki Medical University, Takeda |
| NCT00411554 | Phase 3 | Jan 1, 2007 | Merck |
| NCT00212017 | N/A | Apr 1, 2005 | National Cerebral and Cardiovascular Center |
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Takeda | For profit | 7 | 6 | 4 | 2007 |
| Kawasaki Medical University | Academic/Hospital | 4 | 0 | 2 | 2007 |
| Merck | For profit | 2 | 2 | 1 | 2007 |
| Bayer | For profit | 1 | 1 | 1 | 2009 |
| Boehringer Ingelheim | For profit | 1 | 1 | 1 | 2008 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Government of China | Government | 1 | 1 | 1 | 2008 |
| JW Pharmaceutical | For profit | 1 | 1 | 1 | 2008 |
| National Cerebral and Cardiovascular Center | Government | 1 | 1 | 1 | 2005 |
| Novartis | For profit | 1 | 1 | 1 | 2011 |
| Novo Nordisk | For profit | 1 | 1 | 1 | 2016 |
| Peking University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Postgraduate Institute of Medical Education and Research | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Sanofi | For profit | 1 | 1 | 1 | 2016 |
| University of Zambia | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University Teaching Hospital, Lusaka, Zambia | Academic/Hospital | 1 | 0 | 1 | 2023 |