tandospirone
Small moleculeexperimental
Tandospirone, sold under the brand name Sediel, is an anxiolytic and antidepressant medication used in Japan and China, where it is marketed by Dainippon Sumitomo Pharma. It is a member of the azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone. — Wikipedia
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
4
Earliest trial started Apr 1, 2009 (NCT00890097)
Timeline
2000s
- Jan 1, 2009
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Serotonin 1a (5-HT1a) receptorPARTIAL AGONIST
HTR1A partial agonist
Chemistry & pharmacology
Loading structure…
SMILES
O=C1[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2C(=O)N1CCCCN1CCN(c2ncccn2)CC1- Mol. weight
- 383.5 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL274047 ↗
- WikipediaTandospirone ↗
- ChEMBLCHEMBL2103888 ↗
Also known as
- 3a,4,7,7a-hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1h-isoindole-1,3(2h)-dione
- 4,7-methano-1h-isoindole-1,3(2h)-dione, hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (3aalpha,4beta,7beta,7aalpha)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
- al-8309b
- metanopirone citrate
- sm 3997
- sm-3997
- tandospirone
- tandospirone
- tandospirone
- tandospirone
- tandospirone
- tandospirone
- tandospirone
- tandospirone
- tandospirone citrate
- tandospirone citrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03667677 | Phase 4 | Nov 1, 2018 | Chongqing Medical University |
| NCT03151382 | Phase 4 | May 20, 2017 | Zhejiang University |
| NCT02040883 | Phase 4 | Feb 1, 2014 | Guangzhou Medical University, Guangzhou Psychiatric Hospital |
| NCT01614041 | Phase 4 | Nov 1, 2011 | Huazhong University of Science and Technology, Sumitomo |
| NCT00890097 | Phase 3 | Apr 1, 2009 | Alcon |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Alcon | For profit | 1 | 1 | 1 | 2009 |
| Chongqing Medical University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Guangzhou Medical University | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Guangzhou Psychiatric Hospital | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Huazhong University of Science and Technology | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Sumitomo | For profit | 1 | 1 | 1 | 2011 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2017 |
7 organizations
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