ursolic acid

Small moleculeexperimental

Glycyrrhizin, a component of Chinese medicine licorice root. In Japan glycyrrhizin has been used for more than 20 years as treatment for chronic hepatitis and improves liver function with occasional complete recovery from hepatitis. In randomized controlled trials, glycyrrhizin induced a significant reduction of serum aminotransferases and an improvement in liver histology compared to placebo. Intravenous glycyrrhizin can be used safely and be useful for patients with difficult-to-diagnose acute liver disease as an 'initial' treatment tool to improve liver inflammation before starting disease-specific treatments. The mechanism of anti-inflammatory effect of glycyrrhizin most probably does not involve ROS and this major constituent is not responsible for the inhibition effects of liquorice extract on neutrophil functions. — NCATS

Clinical trial activity

11 trials · 11 clinical orgs · 0 marketing orgs

Phase 1

Phase 2

Phase 3

Phase 4

Earliest trial started Feb 1, 2002 (NCT00759525)

Timeline

2000s

Jan 1, 2002
Earliest Phase 2 Sponsor(trial)
Jan 1, 2006
Earliest Phase 3 Sponsor(trial)

2010s

Jan 1, 2017
Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Hepatitis C, Chronic (approved 1948)

Studied for

Mechanism of action

Unspecified targetUnclear
unclear

Chemistry & pharmacology

Loading structure…

SMILES

CC1(C)[C@@H](O[C@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@@]4(C)[C@]3(C)CC[C@@H]12

Mol. weight: 822.94 g/mol
Lipinski Ro5: 3 violation(s)
Rule of 3: No
Chirality: Single Stereoisomer
Inorganic: No
Polymer: No

Oral

Parenteral

Topical

Sources

Also known as

18beta-glycyrrhizic acid
(3 beta)-3-hydroxyurs-12-en-28-oic acid
3-epi-ursolic acid
arthrodont
biosone
e958
e958
enoxolone
enoxolone
enoxolone
enoxolone
enoxolone
enoxolone
enoxolone
glycyron
glycyrrhetic acid
glycyrrhetic acid
glycyrrhetic acid
glycyrrhetic acid
glycyrrhetic acid
glycyrrhetin
glycyrrhetin
glycyrrhetinic acid
glycyrrhetinic acid
glycyrrhetinic acid
glycyrrhetinic acid
glycyrrhetinic acid glycoside
glycyrrhizic acid
glycyrrhizic acid
glycyrrhizic acid
glycyrrhizic acid
glycyrrhizin
glycyrrhizin
glycyrrhizin
glycyrrhizin
glycyrrhizin
glycyrrhizin
glycyrrhizinate dipotassium
glycyrrhizinic acid
glycyrrhizinic acid
glycyrrhizinic acid
merotaine
nsc-35347
nsc-35347
nsc-35350
nsc-35350
rhetinic acid
rhetinic acid
subglycyrrhelinic acid
uralenic acid
uralenic acid
uralenic acid
ursolic acid
ursolic acid
ursolic acid
ursolic acid, (3beta)-isomer, 2-(14)c-labeled
ursolic acid, (3beta)-isomer, monopotassium salt

Clinical trials

NCT ID	Phase	Start date	Sponsor(s)
NCT05776862	Phase 2	Mar 27, 2023	University of Miami
NCT05570110	Phase 1/Phase 2 (Phase 2)	Sep 23, 2022	Philipps University of Marburg, Slovak Academy of Sciences
NCT05987722	N/A	Jul 30, 2021	Kaohsiung Medical University
NCT04403568	Early Phase 1 (Phase 1)	Jun 30, 2020	University of Texas, San Antonio
NCT04421716	Early Phase 1 (Phase 1)	Jun 30, 2020	University of Texas, San Antonio
NCT03216876	Phase 1	Sep 30, 2017	University of California, Davis
NCT02401113	Phase 2/Phase 3 (Phase 3)	Nov 1, 2014	Pusan National University
NCT02337933	Phase 2	Sep 1, 2014	University of Guadalajara
NCT00686881	Phase 3	Dec 1, 2006	Merck
NCT00384384	Phase 2	Aug 1, 2006	University of Bern
NCT00759525	Phase 2/Phase 3 (Phase 3)	Feb 1, 2002	Harvard University

Showing 11 of 11 trials

Page 1 / 1

Organizations

Research & Development (11)

Organization	Org type	Trials	As lead sponsor	Phases	Earliest year
University of Texas, San Antonio	Academic/Hospital	2	2	1	2020
Harvard University	Academic/Hospital	1	1	1	2002
Kaohsiung Medical University	Academic/Hospital	1	1	1	2021
Merck	For profit	1	1	1	2006
Philipps University of Marburg	Academic/Hospital	1	1	1	2022
Pusan National University	Academic/Hospital	1	1	1	2014
Slovak Academy of Sciences	Government	1	0	1	2022
University of Bern	Academic/Hospital	1	1	1	2006
University of California, Davis	Academic/Hospital	1	1	1	2017
University of Guadalajara	Academic/Hospital	1	1	1	2014
University of Miami	Academic/Hospital	1	1	1	2023

11 organizations

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