tyrosine
Small moleculeapproved
Approved
Jun 1, 1961
Tyrosine (L-form) is a non-essential amino acid, which is primarily required for the protein synthesis. This amino acid is the precursor of dopamine, norepinephrine, and epinephrine; therefore the lower concentration of tyrosine could be a peripheral marker of the hyperdopaminergic condition hypothesized to explain psychosis. Tyrosine supplements can improve cognition, increase energy, reduce anxiety, reduce depression, reduce levels of pain. — NCATS
Clinical trial activity
18 trials · 18 clinical orgs · 1 marketing orgs
Phase 1
2
Phase 2
2
Phase 3
2
Phase 4
0
Earliest trial started Jan 1, 2000 (NCT00302289)
Timeline
Indications
Mechanism of action
- tyrosineOTHER
tyrosine other
Combination products
tpn
with nicotinamide, pyridoxine
Approval history
- approvedJun 1, 1961
- approved—
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CC1=CC=C(O)C=C1)C(O)=O- Mol. weight
- 181.1885 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaTyrosine ↗
- NCATS42HK56048U ↗
- ChEMBLCHEMBL925 ↗
Also known as
- (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid
- (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid
- 4-hydroxy-l-phenylalanine
- 4-hydroxy-l-phenylalanine
- l-tyrosin
- l-tyrosin
- l-tyrosine
- l-tyrosine
- l-tyrosine
- l-tyrosine
- (s)-2-amino-3-(p-hydroxyphenyl)propionic acid
- (s)-2-amino-3-(p-hydroxyphenyl)propionic acid
- (s)-3-(p-hydroxyphenyl)alanine
- (s)-3-(p-hydroxyphenyl)alanine
- (s)-alpha-amino-4-hydroxybenzenepropanoic acid
- (s)-alpha-amino-4-hydroxybenzenepropanoic acid
- (s)-tyrosine
- (s)-tyrosine
- (s)-tyrosine
- (s)-(-)-tyrosine
- (s)-(-)-tyrosine
- (s)-α-amino-4-hydroxybenzenepropanoic acid
- (s)-α-amino-4-hydroxybenzenepropanoic acid
- tyr
- tyr
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- tyrosine
- y
- y
- (−)-α-amino-p-hydroxyhydrocinnamic acid
- (−)-α-amino-p-hydroxyhydrocinnamic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05782829 | N/A | Apr 30, 2023 | University of Nice Sophia Antipolis |
| NCT04518254 | N/A | Sep 30, 2020 | Direction Centrale du Service de Santé des Armées |
| NCT04549194 | N/A | Sep 9, 2020 | Direction Centrale du Service de Santé des Armées |
| NCT04204174 | N/A | Dec 16, 2019 | Tzu Chi University |
| NCT03872557 | N/A | Jun 30, 2019 | Columbia University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
| NCT03278730 | Phase 2 | Mar 1, 2019 | University of Pecs |
| NCT03673995 | N/A | May 2, 2017 | Altamedica Reproductive Medicine, Pharmarte srl |
| NCT02223299 | N/A | Nov 1, 2015 | Department of Veteran Affairs |
| NCT02259049 | Early Phase 1 (Phase 1) | Oct 1, 2014 | New York Institute of Technology |
| NCT02035501 | Phase 2 | Jan 1, 2014 | Hebrew University |
| NCT01823276 | N/A | May 31, 2013 | United States Army |
| NCT01494766 | N/A | Jan 1, 2012 | Seton Healthcare Family |
| NCT00865514 | N/A | Aug 1, 2011 | University of Florida |
| NCT01219049 | N/A | Jan 1, 2010 | Icahn School of Medicine at Mount Sinai |
| NCT01913925 | N/A | Jul 31, 2009 | United States Army |
| NCT00302263 | Phase 2/Phase 3 (Phase 3) | Jan 1, 2005 | Metabolife, Royal Veterinary & Agricultural University, Denmark, University of Copenhagen |
| NCT00302276 | Phase 2/Phase 3 (Phase 3) | Jan 1, 2004 | Royal Veterinary & Agricultural University, Denmark, University of Copenhagen |
| NCT00302289 | Phase 1 | Jan 1, 2000 | Royal Veterinary & Agricultural University, Denmark, University of Copenhagen |
Showing 18 of 18 trials
Page 1 / 1
Organizations
Research & Development (18)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Royal Veterinary & Agricultural University, Denmark | Academic/Hospital | 3 | 0 | 2 | 2000 |
| University of Copenhagen | Academic/Hospital | 3 | 3 | 2 | 2000 |
| Direction Centrale du Service de Santé des Armées | Government | 2 | 2 | 1 | 2020 |
| United States Army | Government | 2 | 2 | 1 | 2009 |
| Altamedica Reproductive Medicine | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Columbia University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2015 |
| Hebrew University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 1 | 1 | 2010 |
| Metabolife | For profit | 1 | 0 | 1 | 2005 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 0 | 1 | 2019 |
| New York Institute of Technology | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Pharmarte srl | For profit | 1 | 1 | 1 | 2017 |
| Seton Healthcare Family | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Tzu Chi University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| University of Florida | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Nice Sophia Antipolis | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Pecs | Academic/Hospital | 1 | 1 | 1 | 2019 |
18 organizations
Page 1 / 1
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| International Minerals and Chemical Corporation | For profit | NDA2 | — |
| International Minerals and Chemical Corporation | For profit | NDA | — |