tti-621
Recombinant proteinexperimental
Clinical trial activity
5 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2016 (NCT02663518)
Timeline
Indications
Studied for
- Breast Neoplasms · Phase 1
- Carcinoma, Merkel Cell · Phase 1
- Carcinoma, Squamous Cell · Phase 1
- Hematologic Neoplasms · Phase 1
- Leiomyosarcoma · Phase 1/Phase 2
- Lymphoma · Phase 2
- Lymphoma, B-Cell · Phase 2
- Lymphoma, Follicular · Phase 2
- Lymphoma, Large B-Cell, Diffuse · Phase 2
- Lymphoma, Large-Cell, Immunoblastic · Phase 2
- Lymphoma, Non-Hodgkin · Phase 2
- Lymphoma, T-Cell · Phase 2
- Melanoma · Phase 1
- Multiple Myeloma · Phase 1
- Mycosis Fungoides · Phase 1
- Neoplasm Metastasis · Phase 1
- Neoplasms · Phase 1
- Sarcoma · Phase 1
Mechanism of action
- Leukocyte surface antigen CD47INHIBITOR
CD47 inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL5314996 ↗
Also known as
- tti-621
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05507541 | Phase 2 | Jan 15, 2023 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT05139225 | Phase 1 | Oct 28, 2021 | Memorial Sloan-Kettering Cancer Center, Trillium Therapeutics Inc. |
| NCT04996004 | Phase 1/Phase 2 (Phase 2) | Jun 25, 2021 | Trillium Therapeutics Inc. |
| NCT02890368 | Phase 1 | Sep 1, 2016 | Trillium Therapeutics Inc. |
| NCT02663518 | Phase 1 | Jan 1, 2016 | Trillium Therapeutics Inc. |
Showing 5 of 5 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Trillium Therapeutics Inc. | For profit | 4 | 3 | 2 | 2016 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Memorial Sloan-Kettering Cancer Center | Academic/Hospital | 1 | 1 | 1 | 2021 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2023 |
4 organizations
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