trimegestone
Small moleculeexperimental
Trimegestone, sold under the brand names Ondeva and Totelle among others, is a progestin medication which is used in menopausal hormone therapy and in the prevention of postmenopausal osteoporosis. It was also under development for use in birth control pills to prevent pregnancy, but ultimately was not marketed for this purpose. The medication is available alone or in combination with an estrogen. It is taken by mouth. — Wikipedia
Clinical trial activity
3 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
2
Earliest trial started Feb 1, 2005 (NCT00195455)
Timeline
2010s
- Jan 1, 2017
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Progesterone receptorAGONIST
PGR agonist
Chemistry & pharmacology
Loading structure…
SMILES
C[C@H](O)C(=O)[C@@]1(C)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3CC[C@@]21C- Mol. weight
- 342.48 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTrimegestone ↗
- ChEMBLCHEMBL2104765 ↗
Also known as
- 17-(2-hydroxy-1-oxopropyl)-17-methylestra-4,9-dien-3-one
- 21-hydroxypromegestone
- ru 27987
- ru-27987
- ru-27987
- ru-27987
- ru 27988
- ru-27988
- trimegeston
- trimegestone
- trimegestone
- trimegestone
- trimegestone
- trimegestone
- trimegestone
- trimegestone
- trimegestone
- trimegestone, (17beta(r))-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03343912 | Phase 1 | Nov 10, 2017 | Galeno Desenvolvimento de Pesquisas, SocraTec R&D GmbH |
| NCT00472004 | Phase 4 | Feb 1, 2006 | Pfizer |
| NCT00195455 | Phase 4 | Feb 1, 2005 | Pfizer, Wyeth |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Pfizer | For profit | 2 | 2 | 1 | 2005 |
| Galeno Desenvolvimento de Pesquisas | Academic/Hospital | 1 | 1 | 1 | 2017 |
| SocraTec R&D GmbH | For profit | 1 | 0 | 1 | 2017 |
| Wyeth | For profit | 1 | 0 | 1 | 2005 |
4 organizations
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