tributyrin
Small moleculeexperimental
Tributyrin is a triglyceride naturally present in butter. It is an ester composed of butyric acid and glycerol. Among other things, it is used as an ingredient in making margarine. It is present in butter and can be described as a liquid fat with an acrid taste. — Wikipedia
Clinical trial activity
8 trials · 10 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Aug 1, 1995 (NCT00002677)
Timeline
Indications
Mechanism of action
- Histone deacetylase 2INHIBITOR
HDAC2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC- Mol. weight
- 302.37 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTributyrin ↗
- ChEMBLCHEMBL118722 ↗
Also known as
- butanoic acid, 1,2,3- propanetriyl ester
- glyceryl tributyrate
- tributyrin
- tributyrin
- tributyrin
- tributyrin
- tributyrylglycerol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07154511 | Phase 1/Phase 2 (Phase 2) | Nov 7, 2025 | Farmer Foundation, University of Michigan |
| NCT06797817 | Phase 3 | Sep 1, 2025 | Universidad de Almeria |
| NCT07004257 | N/A | Jul 1, 2025 | University of British Columbia |
| NCT06501898 | N/A | Aug 19, 2024 | Compound Solutions Inc., Florida State University |
| NCT06700785 | N/A | May 3, 2024 | The Center for Applied Health Sciences, LLC |
| NCT05951153 | Early Phase 1 (Phase 1) | Nov 30, 2023 | Duke University |
| NCT05446168 | Phase 1 | Jul 1, 2022 | University of Michigan |
| NCT00002677 | Phase 1 | Aug 1, 1995 | National Cancer Institute (NCI), University of Maryland |
Showing 8 of 8 trials
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Organizations
Research & Development (10)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Michigan | Academic/Hospital | 2 | 2 | 2 | 2022 |
| Compound Solutions Inc. | For profit | 1 | 0 | 1 | 2024 |
| Duke University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Farmer Foundation | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Florida State University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 1995 |
| The Center for Applied Health Sciences, LLC | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Universidad de Almeria | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of British Columbia | Academic/Hospital | 1 | 1 | 1 | 2025 |
| University of Maryland | Academic/Hospital | 1 | 1 | 1 | 1995 |
10 organizations
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