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tocotrienol

Small moleculeexperimental

Tocotrienols are plant-derived natural products belonging to the vitamin E family of diterpenoids. They exist as four isomers, each differing in the number and position of methyl groups on their chromanol ring. Tocotrienols are distinguished from the closely related tocopherols by their side chains: tocotrienols have three unsaturated isoprenoid double bonds, whereas tocopherols have a fully saturated side chain. — Wikipedia

Clinical trial activity

37 trials · 33 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
20
Phase 3
7
Phase 4
0

Earliest trial started Nov 1, 2001 (NCT01157026)

Timeline

2000s

  1. Jan 1, 2006

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2012

    Earliest Phase 2 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetAntioxidant

    antioxidant

Chemistry & pharmacology

Loading structure…

SMILES

CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC1(C)CCc2cc(O)ccc2O1
Mol. weight
382.59 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • gamma-delta tocotrienol
  • gamma delta tocotrienols
  • mixed tocotrienols
  • tocotrienol
  • tocotrienol
  • tocotrienol
  • tocotrienols
  • tocotrienols
  • tocotrinol

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06519097Phase 2Jul 9, 2024National Cancer Institute (NCI), University of South Florida
NCT05471453N/AMar 2, 2022Kaohsiung Medical University
NCT04491383Phase 2Apr 1, 2021hovid, National Neuroscience Institute, Singapore General Hospital
NCT04704063Phase 2Jan 1, 2021hovid, Monash University, Univerisiti Sains Malaysia
NCT04658823Phase 2Dec 21, 2020Hôpital Lariboisière, hovid
NCT04245865Phase 2Mar 31, 2020Region Syddanmark
NCT04175470Phase 2Oct 29, 2019Region Syddanmark
NCT03705845Phase 1/Phase 2 (Phase 2)Aug 15, 2019Texas Tech University
NCT03708354Phase 1/Phase 2 (Phase 2)Jul 15, 2019Texas Tech University
NCT04140136Phase 2Jun 17, 2019University of Malaya
NCT04900532N/AMay 1, 2019Fluminense Federal University, Wayne State University
NCT03855423N/AFeb 18, 2019Government of Malaysia, University of Malaya
NCT03807037Phase 2/Phase 3 (Phase 3)Dec 17, 2018INSTITUT JANTUNG NEGARA, Monash University
NCT03532763N/AApr 19, 2018Government of Malaysia, University Putra Malaysia
NCT03019263N/AMar 31, 2017University of Pavia
NCT02909751Phase 2Sep 1, 2016Region Syddanmark
NCT02705300Phase 2May 1, 2016Region Syddanmark, University of Southern Denmark
NCT04496492Phase 2Feb 9, 2016University of Milan
NCT02581085Early Phase 1 (Phase 1)Feb 1, 2016Government of Malaysia, Ohio State University
NCT02644252Phase 3Jan 1, 2016Region Syddanmark
Showing 20 of 37 trials
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Organizations

Research & Development (33)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Government of MalaysiaGovernment10642001
Region SyddanmarkAcademic/Hospital7722015
University of MalayaAcademic/Hospital5232009
hovidFor profit3112020
Texas Tech UniversityAcademic/Hospital3312014
University of Southern DenmarkAcademic/Hospital3012015
Monash UniversityAcademic/Hospital2122018
Ohio State UniversityAcademic/Hospital2212006
University of California, Los AngelesAcademic/Hospital2212015
University of Science MalaysiaAcademic/Hospital2112011
University Putra MalaysiaAcademic/Hospital2012012
Carotech Inc.For profit1012006
Clinical Research Centre Hospital TaipingAcademic/Hospital1012015
Clinical Research Centre, MalaysiaAcademic/Hospital1012011
Fluminense Federal UniversityAcademic/Hospital1112019
Hebrew UniversityAcademic/Hospital1112011
Hôpital LariboisièreAcademic/Hospital1012020
INSTITUT JANTUNG NEGARAAcademic/Hospital1012018
Kaohsiung Medical UniversityAcademic/Hospital1112022
Mid-Atlantic Retina Consultations, Inc.Academic/Hospital1112009
33 organizations
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