tetrodotoxin
Small moleculeexperimental
Tetrodotoxin (TTX) is a potent neurotoxin. Its name derives from Tetraodontiformes, an order that includes pufferfish, porcupinefish, ocean sunfish, and triggerfish; several of these species carry the toxin. Although tetrodotoxin was discovered in these fish, it is found in several other animals. It is also produced by certain infectious or symbiotic bacteria like Pseudoalteromonas, Pseudomonas, and Vibrio as well as other species found in symbiotic relationships with animals and plants. — Wikipedia
Clinical trial activity
7 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
2
Phase 4
0
Earliest trial started Apr 1, 2008 (NCT00725114)
Timeline
Indications
Mechanism of action
SCN3A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
NC1=N[C@H](O)[C@H]2[C@H]3O[C@]4(O)O[C@@H]([C@@H](O)[C@@]2(N1)[C@@H]4O)[C@]3(O)CO- Mol. weight
- 319.27 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTetrodotoxin ↗
- ChEMBLCHEMBL507974 ↗
Also known as
- tetrodotoxin
- tetrodotoxin
- tetrodotoxin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06848348 | Phase 2 | Feb 21, 2025 | Dogwood Therapeutics Inc. |
| NCT05359133 | Phase 2 | Apr 19, 2022 | Wex Pharmaceuticals Inc. |
| NCT04083833 | Phase 1 | Feb 7, 2018 | Celerion, Wex Pharmaceuticals Inc. |
| NCT01655823 | Phase 2 | Jul 1, 2012 | Wex Pharmaceuticals Inc. |
| NCT01527734 | Phase 1 | Dec 1, 2011 | Wex Pharmaceuticals Inc. |
| NCT00726011 | Phase 3 | Jul 1, 2008 | University of Calgary, Wex Pharmaceuticals Inc. |
| NCT00725114 | Phase 3 | Apr 1, 2008 | University of Calgary, Wex Pharmaceuticals Inc. |
Showing 7 of 7 trials
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Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Wex Pharmaceuticals Inc. | For profit | 6 | 6 | 3 | 2008 |
| University of Calgary | Academic/Hospital | 2 | 0 | 1 | 2008 |
| Celerion | For profit | 1 | 0 | 1 | 2018 |
| Dogwood Therapeutics Inc. | For profit | 1 | 1 | 1 | 2025 |
4 organizations
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