bradanicline
Small moleculeexperimental
Bradanicline is a drug which was being developed by Targacept that acts as a partial agonist at the α7 subtype of the neural nicotinic acetylcholine receptors. It showed cognitive enhancing effects in animal studies, and was being developed through a collaboration between Targacept and AstraZeneca as a potential treatment for schizophrenia and attention deficit disorder. Phase I clinical trials were completed successfully, and it was in phase II trials. — Wikipedia
Clinical trial activity
6 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2009 (NCT01003379)
Timeline
Indications
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
O=C(N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1)c1cc2ccccc2o1- Mol. weight
- 361.45 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBradanicline ↗
- ChEMBLCHEMBL1258006 ↗
Also known as
- bradanicline
- bradanicline
- bradanicline
- n-(2-(pyridin-3-ylmethyl)-1-azabicyclo(2.2.2)oct-3-yl)-1-benzofuran-2-carboxamide
- tc5619
- tc 5619
- tc-5619
- tc-5619
- tc-5619
- tc-5619
- tc-5619-238
- tc-5619-238
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03622216 | Phase 2 | Nov 30, 2018 | Attenua, Inc. |
| NCT01488929 | Phase 2 | Dec 1, 2011 | Collaborative Neuroscience Network, Targacept |
| NCT01472991 | Phase 2 | Nov 1, 2011 | Harvard University, Targacept |
| NCT01254448 | Phase 1 | Sep 1, 2010 | Comprehensive Clinical Development, Inc., Targacept |
| NCT01124708 | Phase 2 | May 1, 2010 | Fletcher Allen Hospital, Targacept |
| NCT01003379 | Phase 2 | Oct 1, 2009 | Columbia University, Targacept |
Showing 6 of 6 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Targacept | For profit | 5 | 5 | 2 | 2009 |
| Attenua, Inc. | For profit | 1 | 1 | 1 | 2018 |
| Collaborative Neuroscience Network | For profit | 1 | 0 | 1 | 2011 |
| Columbia University | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Comprehensive Clinical Development, Inc. | For profit | 1 | 0 | 1 | 2010 |
| Fletcher Allen Hospital | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2011 |
7 organizations
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