talarozole
Small moleculeexperimental
Talarozole was an investigational drug for the treatment of acne, psoriasis and other keratinization disorders. Development for that purpose has been discontinued. However, its effect in increasing retinoic acid is now being investigated in hand and knee osteoarthritis. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2004 (NCT00725348)
Timeline
Indications
Mechanism of action
- Cytochrome P450 26A1INHIBITOR
CYP26A1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCC(CC)C(c1ccc(Nc2nc3ccccc3s2)cc1)n1cncn1- Mol. weight
- 377.52 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTalarozole ↗
- ChEMBLCHEMBL459505 ↗
Also known as
- n-(4-(2-ethyl-1-(1h-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine
- r115866
- r 115866
- r-115866
- r-115866
- r-115866
- rambazole
- rambazole
- rambazole
- talarozole
- talarozole
- talarozole
- talarozole
- talarozole
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00719121 | Phase 1 | Nov 1, 2006 | Stiefel Laboratories, Universitaire du Sart-Tilman |
| NCT00716144 | Phase 2 | Jun 1, 2006 | Stiefel Laboratories, University of Manchester |
| NCT00725439 | Phase 2 | Sep 1, 2004 | Stiefel Laboratories, University of Brussels |
| NCT00725348 | Phase 2 | Apr 1, 2004 | Stiefel Laboratories, University of Nijmegen |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Stiefel Laboratories | For profit | 4 | 4 | 2 | 2004 |
| Universitaire du Sart-Tilman | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Brussels | Academic/Hospital | 1 | 0 | 1 | 2004 |
| University of Manchester | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Nijmegen | Academic/Hospital | 1 | 0 | 1 | 2004 |
5 organizations
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