amsacrine
Small moleculeexperimental
Clinical trial activity
10 trials · 16 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
8
Phase 3
6
Phase 4
1
Earliest trial started Nov 1, 1986 (NCT01324063)
Timeline
Indications
Approved for
Mechanism of action
- DNA topoisomerase IIINHIBITOR
DNA topoisomerase II inhibitor
Amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis.
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12- Mol. weight
- 393.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL43 ↗
Also known as
- 4'-(9-acridinylamino)-3'-methoxymethanesulfonanilide
- 4'-(9-acridinylamino)-3'-methoxymethanesulfonanilide
- 4'-(9-acridinylamino)methanesulfon-m-anisidide
- 4'-(9-acridinylamino)methanesulfon-m-anisidide
- 4'-(9-acridinylamino)methanesulfon-meta-anisidide
- 4'-(9-acridinylamino)methanesulfon-meta-anisidide
- 4'-(9-acridinylamino)methanesulphon-m-anisidide
- 4'-(9-acridinylamino)methanesulphon-m-anisidide
- acridinylanisidide
- acridinyl anisidide
- acridinyl anisidide
- amekrin
- amsacrine
- amsacrine
- amsacrine
- amsacrine
- amsacrine
- amsacrine
- amsacrine
- amsacrine
- amsidil
- amsidine
- amsidyl
- amsidyl
- amsidyl
- ci-880
- ci-880
- lamasine
- mamsa
- mamsa
- m-amsa
- m-amsa
- m-amsa
- nci-249992
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05807932 | Phase 1/Phase 2 (Phase 2) | Jun 26, 2023 | University of Duesseldorf |
| NCT03765541 | Phase 3 | Sep 30, 2019 | University of Toulouse |
| NCT01423175 | Phase 2 | Jul 1, 2011 | Genzyme, Gottfried Wilhelm Leibniz Universität Hannover, Hannover Clinical Trial Center GmbH |
| NCT01228331 | Phase 2/Phase 3 (Phase 3) | Oct 1, 2010 | University of Hamburg |
| NCT00840684 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2009 | Institut Paoli-Calmettes |
| NCT00180102 | Phase 4 | Dec 1, 2003 | Technical University of Dresden |
| NCT00003436 | Phase 3 | Jul 1, 1998 | Medical Research Council, The Christie NHS Foundation Trust |
| NCT00002719 | Phase 3 | Dec 1, 1995 | European Organisation for Research and Treatment of Cancer, Gruppo Italiano Malattie EMatologiche dell'Adulto, Leiden University, University of Roma La Sapienza |
| NCT00002658 | Phase 3 | Jan 1, 1994 | Cardiff University, Medical Research Council |
| NCT01324063 | Phase 3 | Nov 1, 1986 | European Organisation for Research and Treatment of Cancer, University of Paris |
Showing 10 of 10 trials
Page 1 / 1
Organizations
Research & Development (16)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 2 | 2 | 1 | 1986 |
| Medical Research Council | Government | 2 | 2 | 1 | 1994 |
| Cardiff University | Academic/Hospital | 1 | 0 | 1 | 1994 |
| Genzyme | For profit | 1 | 0 | 1 | 2011 |
| Gottfried Wilhelm Leibniz Universität Hannover | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Gruppo Italiano Malattie EMatologiche dell'Adulto | Academic/Hospital | 1 | 0 | 1 | 1995 |
| Hannover Clinical Trial Center GmbH | For profit | 1 | 0 | 1 | 2011 |
| Institut Paoli-Calmettes | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Leiden University | Academic/Hospital | 1 | 0 | 1 | 1995 |
| Technical University of Dresden | Academic/Hospital | 1 | 1 | 1 | 2003 |
| The Christie NHS Foundation Trust | Academic/Hospital | 1 | 0 | 1 | 1998 |
| University of Duesseldorf | Academic/Hospital | 1 | 1 | 1 | 2023 |
| University of Hamburg | Academic/Hospital | 1 | 1 | 1 | 2010 |
| University of Paris | Academic/Hospital | 1 | 0 | 1 | 1986 |
| University of Roma La Sapienza | Academic/Hospital | 1 | 0 | 1 | 1995 |
| University of Toulouse | Academic/Hospital | 1 | 1 | 1 | 2019 |
16 organizations
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