sivelestat
Small moleculeexperimental
Sivelestat is an inhibitor of human neutrophil elastase. — Wikipedia
Clinical trial activity
15 trials · 19 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
1
Phase 4
3
Earliest trial started Aug 1, 2001 (NCT00036062)
Timeline
Indications
Approved for
Studied for
- Acute Lung Injury · Phase 4
- Aortic Dissection · Phase 4
- Bleeding Time · Phase 2
- Community-Acquired Infections · Phase 2
- Multiple Organ Failure · Phase 4
- Respiratory Distress Syndrome · Phase 4
- Severe Acute Respiratory Syndrome · Phase 3
- Shock, Septic · Phase 2
- Systemic Inflammatory Response Syndrome · Phase 4
Mechanism of action
- Elastase 1INHIBITOR
CELA1 inhibitor
- Leukocyte elastaseINHIBITOR
Leukocyte elastase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(C)C(=O)Oc1ccc(S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)[O-])cc1.O.O.O.O.[Na+]- Mol. weight
- 528.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3182314 ↗
- WikipediaSivelestat ↗
- ChEMBLCHEMBL76688 ↗
- ChEMBLCHEMBL2107493 ↗
Also known as
- glycine, n-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-
- n-(2-(4-(2,2-dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
- ono 5046
- ono-5046
- ono-5046
- ono-5046
- ono-5046
- ono-5046.na
- ono-5046.na
- ono-ei-600
- sivelestat
- sivelestat
- sivelestat
- sivelestat
- sivelestat
- sivelestat
- sivelestat
- sivelestat
- sivelestat sodium
- sivelestat sodium
- sivelestat sodium hydrate
- sivelestat sodium hydrate
- sivelstat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07214103 | Phase 2 | Mar 1, 2026 | University of Strasbourg |
| NCT07196605 | N/A | Oct 1, 2025 | Capital Medical University |
| NCT07156656 | Phase 4 | Sep 1, 2025 | Anhui Medical University, Changhai Hospital, Fudan University, Fujian Provincial Hospital, Jiao Tong University, Shantou University, The University of Hong Kong |
| NCT06387823 | N/A | Apr 15, 2024 | Chinese Academy of Medical Sciences, Government of China, Peking University |
| NCT05874700 | N/A | May 31, 2023 | Capital Medical University |
| NCT05697016 | N/A | Jan 31, 2023 | Capital Medical University |
| NCT05672472 | N/A | Jan 10, 2023 | Jinlin University |
| NCT05343338 | N/A | Apr 20, 2022 | Jiao Tong University |
| NCT04973670 | Phase 3 | Oct 11, 2021 | Southeast University |
| NCT04909697 | Phase 4 | Jul 1, 2021 | Sichuan University |
| NCT00738348 | N/A | Apr 1, 2007 | Kochi University |
| NCT01170845 | N/A | Mar 1, 2007 | Yokohama City University |
| NCT00417326 | Phase 2 | Dec 1, 2006 | Ono Pharmaceuticals |
| NCT00219375 | Phase 4 | Jun 1, 2004 | Ono Pharmaceuticals |
| NCT00036062 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2001 | Eli Lilly |
Showing 15 of 15 trials
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Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Capital Medical University | Academic/Hospital | 3 | 3 | 1 | 2023 |
| Jiao Tong University | Academic/Hospital | 2 | 1 | 2 | 2022 |
| Ono Pharmaceuticals | For profit | 2 | 2 | 2 | 2004 |
| Anhui Medical University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Changhai Hospital | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Chinese Academy of Medical Sciences | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Eli Lilly | For profit | 1 | 1 | 1 | 2001 |
| Fudan University | Academic/Hospital | 1 | 1 | 1 | 2025 |
| Fujian Provincial Hospital | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Government of China | Government | 1 | 0 | 1 | 2024 |
| Jinlin University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Kochi University | Academic/Hospital | 1 | 1 | 1 | 2007 |
| Peking University | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Shantou University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Sichuan University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Southeast University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| The University of Hong Kong | Academic/Hospital | 1 | 0 | 1 | 2025 |
| University of Strasbourg | Academic/Hospital | 1 | 1 | 1 | 2026 |
| Yokohama City University | Academic/Hospital | 1 | 1 | 1 | 2007 |
19 organizations
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