sitafloxacin
Small moleculeexperimental
Clinical trial activity
8 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
5
Phase 3
4
Phase 4
2
Earliest trial started Nov 1, 2012 (NCT02537847)
Timeline
Indications
Approved for
Studied for
- Anti-Infective Agents, Urinary · Phase 2/Phase 3
- Bronchiectasis · Phase 4
- Escherichia coli Infections · Phase 2/Phase 3
- Fluoroquinolones · Phase 2
- Kidney Transplantation · Phase 2/Phase 3
- Klebsiella Infections · Phase 2/Phase 3
- Mycobacterium · Phase 2
- Pulmonary Disease, Chronic Obstructive · Phase 4
- Pyelonephritis · Phase 2
- Tuberculosis, Pulmonary · Phase 3
- Urinary Tract Infections · Phase 2/Phase 3
Mechanism of action
- Topoisomerase IVINHIBITOR
Topoisomerase IV inhibitor
- DNA gyraseINHIBITOR
DNA gyrase inhibitor
- Topoisomerase IVINHIBITOR
Topoisomerase IV inhibitor
- Bacterial DNA gyraseINHIBITOR
Bacterial DNA gyrase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H]1CN(c2c(F)cc3c(=O)c(C(=O)O)cn([C@@H]4C[C@@H]4F)c3c2Cl)CC12CC2.O- Mol. weight
- 427.84 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989504 ↗
- ChEMBLCHEMBL108821 ↗
Also known as
- 3-quinolinecarboxylic acid, 7-(7-amino-5-azaspiro(2.4)hept-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-, (1r-(1alpha(s*),2alpha))-
- 7-(7-amino-5-azaspiro(2.4)heptan-5-yl)-8-chloro-6-fluoro-1-(2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid sesquihydrate
- 7-((7s)-amino-5-azaspiro(2,4)heptan-5-yl)-8-chloro-6-fluoro-1-((1r,2r)-cis-2-fluoro-1-cyclopropyl)-1,4-dihydro-4-oxoquinolone-3-carboxylic acid
- du 6859
- du-6859
- du-6859
- du 6859a
- du-6859a
- du-6859a
- du-6859a
- gracevit
- sitafloxacin
- sitafloxacin
- sitafloxacin
- sitafloxacin
- sitafloxacin
- sitafloxacin
- sitafloxacin
- sitafloxacin hydrate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07076225 | Phase 3 | Jul 25, 2025 | Capital Medical University, Fudan University, Huazhong University of Science and Technology, Shenzhen Third People's Hospital, Sichuan University, Tsinghua University |
| NCT06905522 | Phase 3 | Apr 15, 2025 | Shenyang Tenth People's Hospital, Shenzhen Third People's Hospital, Zhejiang University |
| NCT06809413 | Phase 2 | Jan 28, 2025 | Capital Medical University |
| NCT05454345 | Phase 3 | Oct 1, 2022 | Zhejiang University |
| NCT05400369 | Phase 4 | Aug 10, 2022 | Daiichi Sankyo |
| NCT05313750 | Phase 4 | Jun 30, 2021 | Huazhong University of Science and Technology |
| NCT02729116 | Phase 2/Phase 3 (Phase 3) | Mar 1, 2016 | KhonKaen University |
| NCT02537847 | Phase 2 | Nov 1, 2012 | Mahidol University |
Showing 8 of 8 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Capital Medical University | Academic/Hospital | 2 | 1 | 2 | 2025 |
| Huazhong University of Science and Technology | Academic/Hospital | 2 | 1 | 2 | 2021 |
| Shenzhen Third People's Hospital | Academic/Hospital | 2 | 2 | 1 | 2025 |
| Zhejiang University | Academic/Hospital | 2 | 1 | 1 | 2022 |
| Daiichi Sankyo | For profit | 1 | 1 | 1 | 2022 |
| Fudan University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| KhonKaen University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Mahidol University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Shenyang Tenth People's Hospital | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Sichuan University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Tsinghua University | Academic/Hospital | 1 | 0 | 1 | 2025 |
11 organizations
Page 1 / 1