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technetium tc-99m sestamibi

Trade name: Cardiolite

Small moleculeapproved

Approved

Dec 21, 1990

Clinical trial activity

24 trials · 17 clinical orgs · 8 marketing orgs

Phase 1
5
Phase 2
8
Phase 3
3
Phase 4
4

Earliest trial started Sep 1, 2003 (NCT00069160)

Timeline

1990s

  1. Dec 21, 1990

    Lantheus Medical Imaging — Earliest FDA Approval

  2. Dec 21, 1990

    Lantheus Medical Imaging — NDA Secondary Org

  3. Dec 21, 1990

    Lantheus Medical Imaging — NDA Organization

2000s

  1. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2005

    Lantheus Medical Imaging — Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2005

    Lantheus Medical Imaging — Earliest Phase 3 Sponsor(trial)

  4. Sep 22, 2008

    Curium Pharma — Marketing Organization

  5. Sep 22, 2008

    Mallinckrodt — Marketing Organization

  6. Apr 28, 2009

    Cardinal Health — Marketing Organization

  7. Apr 29, 2009

    Jubilant DraxImage Inc. — Marketing Organization

  8. Apr 29, 2009

    Jubilant Innovation Ltd. — Marketing Organization

  9. Jul 10, 2009

    Sun Pharmaceuticals — Marketing Organization

  10. Jul 10, 2009

    Pharmalucence — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetOTHER

    Diagnostic agent

  • contrast mediumRadiopaque

    contrast medium radiopaque

Approval history

  • approvedDec 21, 1990

Chemistry & pharmacology

Mol. weight
783.91 g/mol
Chirality
Achiral Molecule
Inorganic
No
Polymer
No
Delivery
Parenteral
Availability
Prescription Only

Oral

No

Parenteral

Yes

Topical

No

Sources

Also known as

  • 99m tc-sestamibi
  • 99m tc-sestamibi
  • 99m-tc sestamibi
  • 99m-tc sestamibi
  • 99mtc sestamibi
  • 99mtc sestamibi
  • 99mtc sestamibi
  • 99mtc-sestamibi
  • 99mtc-sestamibi
  • 99mtc-sestamibi
  • cardiolite
  • cardiolite
  • cardiolite
  • cardiolite
  • miraluma
  • miraluma
  • mtc99 sestamibi
  • sestamibi
  • sestamibi
  • sestamibi
  • tc-99m-rp-30a
  • tc 99m sestamibi
  • tc-99m sestamibi
  • tc99m sestamibi
  • technetium (99m tc) sestamibi
  • technetium (99m tc) sestamibi
  • technetium (99m tc) sestamibi
  • technetium (99mtc) sestamibi
  • technetium (99mtc) sestamibi
  • technetium (99mtc) sestamibi
  • technetium (99mtc) sestamibi
  • technetium (99mtc) sestamibi
  • technetium tc 99m sestamibi
  • technetium tc 99m sestamibi
  • technetium tc 99m sestamibi
  • technetium tc 99m sestamibi
  • technetium tc-99m sestamibi
  • technetium tc-99m sestamibi
  • technetium tc-99m sestamibi
  • technetium tc-99m sestamibi
  • technetium tc-99m sestamibi kit
  • technetium tc-99m sestamibi kit
  • technetium tc-99 sestamibi

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05042687Early Phase 1 (Phase 1)Sep 30, 2021University of Texas at Houston
NCT06058650N/AAug 26, 2021Mayo Clinic
NCT01899833Phase 2Apr 3, 2017Cell>Point LLC
NCT02744053Early Phase 1 (Phase 1)Nov 1, 2016General Electric, University of Texas at Houston
NCT03065218Phase 4Oct 31, 2016Georgetown University
NCT02324387N/AJun 1, 2015University of Texas at Houston
NCT02160925N/AMay 31, 2014Johns Hopkins University
NCT01944215Phase 1Sep 1, 2013Mayo Clinic, National Cancer Institute (NCI)
NCT02869126N/ASep 1, 2012University of Lorraine
NCT01499654N/AOct 1, 2011Astellas, Northwestern University
NCT01347710Phase 3Jun 1, 2011Lantheus Medical Imaging
NCT01334918Phase 2Apr 1, 2011Astellas
NCT01379677Phase 3Feb 1, 2011Advanced Accelerator Applications, University of London
NCT01925170N/AApr 1, 2009Mayo Clinic, Susan G. Komen Breast Cancer Foundation
NCT00972205N/ADec 1, 2007National Cancer Institute (NCI), National Institutes of Health (NIH)
NCT00560495Phase 1May 1, 2007National Cancer Institute (NCI), State University of New York, Buffalo
NCT00162032Phase 3Aug 1, 2005Lantheus Medical Imaging
NCT00620373N/AAug 1, 2005Mayo Clinic, Susan G. Komen Breast Cancer Foundation
NCT00162331Phase 4Jan 1, 2005Lantheus Medical Imaging
NCT00162045Phase 1/Phase 2 (Phase 2)Jan 1, 2005Lantheus Medical Imaging
Showing 20 of 24 trials
Page 1 / 2

Organizations

Research & Development (17)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Lantheus Medical ImagingFor profit6632003
National Cancer Institute (NCI)Government5332003
Mayo ClinicAcademic/Hospital4422005
National Institutes of Health (NIH)Government3022003
University of Texas at HoustonAcademic/Hospital3322015
AstellasFor profit2122011
Susan G. Komen Breast Cancer FoundationAcademic/Hospital2012005
Advanced Accelerator ApplicationsFor profit1112011
Bristol-Myers SquibbFor profit1012003
Cell>Point LLCFor profit1112017
General ElectricFor profit1012016
Georgetown UniversityAcademic/Hospital1112016
Johns Hopkins UniversityAcademic/Hospital1112014
Northwestern UniversityAcademic/Hospital1112011
State University of New York, BuffaloAcademic/Hospital1112007
University of LondonAcademic/Hospital1012011
University of LorraineAcademic/Hospital1112012
17 organizations
Page 1 / 1

Marketing (9)

OrganizationOrg typeRelationshipDate
Cardinal HealthAcademic/HospitalMKTGApr 28, 2009
Curium PharmaFor profitMKTGSep 22, 2008
Jubilant DraxImage Inc.For profitMKTGApr 29, 2009
Jubilant Innovation Ltd.For profitMKTGApr 29, 2009
Lantheus Medical ImagingFor profitNDA2Dec 21, 1990
Lantheus Medical ImagingFor profitNDADec 21, 1990
MallinckrodtFor profitMKTGSep 22, 2008
PharmalucenceFor profitMKTGJul 10, 2009
Sun PharmaceuticalsFor profitMKTGJul 10, 2009