sabarubicin
Small moleculeexperimental
Sabarubicin (MEN-10755), a disaccharide analog of doxorubicin, is used for the treatment of small cell lung cancer (SCLC). It has been seen to show superior antitumour efficacy, which is purported to be linked to the activation of p53-independent apoptosis — Wikipedia
Clinical trial activity
3 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 1997 (NCT00003028)
Timeline
Indications
Mechanism of action
- DNA topoisomerase IIINHIBITOR
DNA topoisomerase II inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H]1O[C@@H](O[C@@H]2[C@H](C)O[C@@H](O[C@H]3C[C@](O)(C(=O)CO)Cc4c(O)c5c(c(O)c43)C(=O)c3ccccc3C5=O)C[C@@H]2O)C[C@H](N)[C@@H]1O- Mol. weight
- 643.64 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1230227 ↗
- WikipediaSabarubicin ↗
- ChEMBLCHEMBL591251 ↗
Also known as
- 4-demethoxy-7-o-(2,6-dideoxy-4-o-(2,3,6-trideoxy-3-amino-alpha-l-lyxo-hexopyranosyl)-alpha-l-lyxo-hexopyranosyl)-adriamycinone
- men 10755
- men-10755
- men-10755
- men-10755
- sabarubicin
- sabarubicin
- sabarubicin
- sabarubicin
- sabarubicin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00027781 | Phase 2 | Aug 1, 2001 | European Organisation for Research and Treatment of Cancer, University of Hamburg |
| NCT00003982 | Phase 1 | Jun 1, 1997 | European Organisation for Research and Treatment of Cancer, University of Groningen |
| NCT00003028 | Phase 1 | Apr 1, 1997 | European Organisation for Research and Treatment of Cancer, University of Copenhagen |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| European Organisation for Research and Treatment of Cancer | Academic/Hospital | 3 | 3 | 2 | 1997 |
| University of Copenhagen | Academic/Hospital | 1 | 0 | 1 | 1997 |
| University of Groningen | Academic/Hospital | 1 | 0 | 1 | 1997 |
| University of Hamburg | Academic/Hospital | 1 | 0 | 1 | 2001 |
4 organizations
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