amdoxovir
Small moleculeexperimental
Amdoxovir is a pharmaceutical drug that has undergone research for the treatment of HIV/AIDS. It acts as a nucleoside reverse transcriptase inhibitor (NRTI). The drug was discovered by Raymond F. Schinazi and C.K. Chu and developed by RFS Pharma. — Wikipedia
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started Feb 20, 2002 (NCT00031044)
Timeline
Indications
Studied for
Mechanism of action
- Reverse transcriptaseINHIBITOR
Reverse transcriptase inhibitor
Human immunodeficiency virus type 1 reverse transcriptase inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Nc1nc(N)c2ncn([C@H]3CO[C@@H](CO)O3)c2n1- Mol. weight
- 252.23 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAmdoxovir ↗
- ChEMBLCHEMBL458876 ↗
Also known as
- 2,6-diaminopurine dioxolane
- 4-(2,6-diamino-9h-purin-9-yl)-1,3,-dioxolane-2-methanol
- amdoxovir
- amdoxovir
- amdoxovir
- amdoxovir
- dapd
- dapd
- (-)-dapd
- (-)-dapd
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01738555 | Phase 2 | Apr 1, 2013 | RFS Pharma |
| NCT01737359 | Phase 2 | Dec 1, 2012 | RFS Pharma |
| NCT00432016 | Phase 1/Phase 2 (Phase 2) | Feb 1, 2007 | Hospital Privado Modelo, RFS Pharma |
| NCT00038272 | Phase 2 | May 29, 2002 | National Institute of Allergy and Infectious Diseases (NIAID), The University of Texas, Dallas |
| NCT00031044 | Phase 1/Phase 2 (Phase 2) | Feb 20, 2002 | Columbia University, Harvard University, National Institute of Allergy and Infectious Diseases (NIAID) |
Showing 5 of 5 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| RFS Pharma | For profit | 3 | 3 | 1 | 2007 |
| National Institute of Allergy and Infectious Diseases (NIAID) | Government | 2 | 2 | 1 | 2002 |
| Columbia University | Academic/Hospital | 1 | 0 | 1 | 2002 |
| Harvard University | Academic/Hospital | 1 | 0 | 1 | 2002 |
| Hospital Privado Modelo | Academic/Hospital | 1 | 0 | 1 | 2007 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 0 | 1 | 2002 |
6 organizations
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