ritanserin

Small moleculeexperimental

Ritanserin, also known by its developmental code name R-55667, is a serotonin antagonist medication described as an anxiolytic, antidepressant, antiparkinsonian agent, and antihypertensive agent. It was chiefly investigated as a drug to treat insomnia, especially to enhance sleep quality by significantly increasing slow wave sleep by virtue of potent and concomitant 5-HT2A and 5-HT2C receptor antagonism. — Wikipedia

Clinical trial activity

1 trials · 2 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
1
Phase 3
0
Phase 4
0

Earliest trial started Jul 1, 1992 (NCT00000187)

Timeline

1990s

  1. Jan 1, 1992

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

Cc1nc2sccn2c(=O)c1CCN1CCC(=C(c2ccc(F)cc2)c2ccc(F)cc2)CC1
Mol. weight
477.58 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • r-55667
  • r-55667
  • ritanserin
  • ritanserin
  • ritanserin
  • ritanserin
  • tiserton
  • tiserton

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT00000187Phase 2Jul 1, 1992National Institute on Drug Abuse (NIDA), University of Pennsylvania
Showing 1 of 1 trials
Page 1 / 1

Organizations

Research & Development (2)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Institute on Drug Abuse (NIDA)Government1011992
University of PennsylvaniaAcademic/Hospital1111992
2 organizations
Page 1 / 1