thrombopoietin
Recombinant proteinexperimental
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene. — Wikipedia
Clinical trial activity
57 trials · 69 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
30
Phase 3
25
Phase 4
11
Earliest trial started Nov 1, 1998 (NCT00003597)
Timeline
Indications
Approved for
Studied for
- Acute-On-Chronic Liver Failure · Phase 1
- Allografts · Phase 3
- Anemia, Aplastic · Phase 4
- Blood Platelet Disorders · Phase 4
- Blood Transfusion · Phase 4
- Breast Neoplasms · Phase 1/Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2/Phase 3
- Chemoradiotherapy · Phase 2
- Colorectal Neoplasms · Phase 2
- Drug-Related Side Effects and Adverse Reactions · Phase 3
- Drugs, Investigational · Phase 3
- Esophageal Neoplasms · Phase 2
- Healthy Volunteers · Phase 1
- Hematologic Diseases · Phase 3
- Hematopoietic Stem Cell Mobilization · Phase 1/Phase 2
- Hematopoietic Stem Cell Transplantation · Phase 4
- Inosine Triphosphate · Phase 4
- Leukemia · Phase 1/Phase 2
- Leukemia, Myeloid, Acute · Phase 3
- Liver Cirrhosis · Early Phase 1
- Liver Neoplasms · Phase 1/Phase 2
- Lymphoma · Phase 1/Phase 2
- Multiple Myeloma · Phase 1/Phase 2
- Myeloablative Agonists · Phase 4
- Myelodysplastic-Myeloproliferative Diseases · Phase 1/Phase 2
- Myelodysplastic Syndromes · Phase 2/Phase 3
- Neoplasms · Phase 4
- Neoplasms, Germ Cell and Embryonal · Phase 1/Phase 2
- Neuroblastoma · Phase 1/Phase 2
- Osteosarcoma · Phase 1/Phase 2
- Pharmacokinetics · Phase 4
- Pneumonia · Phase 4
- Pregnancy · Phase 3
- Pregnancy Complications · Phase 2
- Purpura · Phase 3
- Purpura, Thrombocytopenic, Idiopathic · Phase 3
- Radiation Oncology · Phase 2
- Rhabdomyosarcoma · Phase 1/Phase 2
- Sarcoma · Phase 3
- Sepsis · Phase 2/Phase 3
- Thrombocytopenia · Phase 4
- Thrombopoietin · Phase 1/Phase 2
Mechanism of action
- ThrombopoietinSupplementation
THPO supplementation
Chemistry & pharmacology
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaThrombopoietin ↗
- ChEMBLCHEMBL4802180 ↗
Also known as
- thrombopoietin
- thrombopoietin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07001397 | Phase 3 | Jun 23, 2025 | Chinese Academy of Medical Sciences |
| NCT06955858 | N/A | May 30, 2025 | China Academy of Chinese Medical Sciences |
| NCT06630494 | Phase 1 | Oct 3, 2024 | Nucleus Network Ltd, Sunshine Lake Pharma Co., Ltd. |
| NCT06525948 | Phase 4 | Jul 30, 2024 | Chinese Academy of Medical Sciences |
| NCT06440824 | Phase 3 | Jun 1, 2024 | Shandong University |
| NCT06254287 | Phase 2 | Feb 1, 2024 | China Academy of Chinese Medical Sciences |
| NCT06004791 | Phase 4 | Aug 31, 2023 | Chinese Academy of Medical Sciences |
| NCT05944809 | Phase 2 | Jul 15, 2023 | Chinese Academy of Medical Sciences |
| NCT05718856 | Phase 4 | Feb 23, 2023 | Capital Medical University, China Academy of Chinese Medical Sciences, Henan Medical University, Kunming Medical University, Tianjin Medical University, Xiamen University |
| NCT05669079 | Phase 3 | Feb 1, 2023 | Soochow University |
| NCT05634824 | Phase 2 | Jan 1, 2023 | Peking University |
| NCT05583838 | Phase 4 | Oct 31, 2022 | China Academy of Chinese Medical Sciences, Chinese Academy of Medical Sciences, Dalian Medical University, Guangzhou Medical University, Harbin Medical University, Henan Medical University, Inner Mongolia Medical University, Jiao Tong University, Kashgar 1st People's Hospital, Kunming Medical University, North China University of Science and Technology Affiliated Hospital, Shaanxi Provincial People's Hospital, Shanxi Medical University, Sunshine Lake Pharma Co., Ltd., Xijing Hospital, Xinjiang Medical University, Yuyao People's Hospital of Zhejiang Province |
| NCT05411705 | Phase 4 | Jun 6, 2022 | Anqing Municipal Hospital, Bethune Charitable Foundation, Chinese Academy of Medical Sciences, Dalian Medical University, Hebei University, Henan Medical University, Henan Provincal People's Hospital, Huazhong University of Science and Technology, Nantong University, Peking University, People's Liberation Army of China, Shaanxi Provincial People's Hospital, Tianjin Medical University |
| NCT05350956 | Phase 2 | Jun 1, 2022 | Hengrui Therapeutics, Inc., Zhengzhou University |
| NCT05217719 | Phase 4 | Feb 28, 2022 | Southern Medical University, The Second People's Hospital of GuangDong Province |
| NCT05382390 | Phase 3 | Jan 21, 2022 | Shengjing Hospital |
| NCT05258799 | N/A | Jan 21, 2022 | Shengjing Hospital |
| NCT05193201 | Phase 1 | Jan 16, 2022 | Peking University, Sunshine Lake Pharma Co., Ltd. |
| NCT05328804 | Phase 3 | Jan 1, 2022 | Soochow University |
| NCT05143892 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2021 | Soochow University |
Showing 20 of 57 trials
Page 1 / 3
Organizations
Research & Development (69)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Chinese Academy of Medical Sciences | Academic/Hospital | 11 | 7 | 3 | 2009 |
| Shandong University | Academic/Hospital | 11 | 11 | 1 | 2009 |
| Peking University | Academic/Hospital | 8 | 4 | 4 | 2014 |
| Dalian Medical University | Academic/Hospital | 6 | 1 | 2 | 2011 |
| Shandong Provincial Hospital | Academic/Hospital | 6 | 0 | 1 | 2009 |
| Sunshine Lake Pharma Co., Ltd. | For profit | 6 | 4 | 3 | 2011 |
| People's Liberation Army of China | Government | 5 | 0 | 2 | 2010 |
| China Academy of Chinese Medical Sciences | Academic/Hospital | 4 | 4 | 3 | 2022 |
| China Medical University | Academic/Hospital | 4 | 1 | 1 | 2011 |
| Huazhong University of Science and Technology | Academic/Hospital | 4 | 1 | 2 | 2009 |
| Soochow University | Academic/Hospital | 4 | 4 | 1 | 2015 |
| Southern Medical University | Academic/Hospital | 4 | 3 | 2 | 2010 |
| Henan Medical University | Academic/Hospital | 3 | 0 | 1 | 2022 |
| Jiao Tong University | Academic/Hospital | 3 | 2 | 2 | 2016 |
| Shantou University | Academic/Hospital | 3 | 0 | 2 | 2010 |
| Shengjing Hospital | Academic/Hospital | 3 | 3 | 2 | 2019 |
| Sun Yat-Sen University | Academic/Hospital | 3 | 0 | 2 | 2009 |
| Tianjin Medical University | Academic/Hospital | 3 | 0 | 2 | 2016 |
| Anhui Medical University | Academic/Hospital | 2 | 0 | 1 | 2012 |
| Capital Medical University | Academic/Hospital | 2 | 0 | 2 | 2013 |
69 organizations
Page 1 / 4