rebimastat
Small moleculeexperimental
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
1
Phase 4
0
Earliest trial started Apr 1, 2000 (NCT00006229)
Timeline
Indications
Mechanism of action
- Matrix metalloproteinase 13INHIBITOR
Matrix metalloproteinase 13 inhibitor
Lower potency against MMP-3
- Matrix metalloproteinase 8INHIBITOR
MMP8 inhibitor
- Matrix metalloproteinase-2INHIBITOR
MMP2 inhibitor
- Matrix metalloproteinase 14INHIBITOR
MMP14 inhibitor
- Matrix metalloproteinase-1INHIBITOR
MMP1 inhibitor
- Matrix metalloproteinase 9INHIBITOR
MMP9 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](S)CCN1C(=O)N(C)C(C)(C)C1=O)C(C)(C)C- Mol. weight
- 499.68 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL76222 ↗
Also known as
- bms-275291
- bms-275291
- bms-275291
- bms-275291
- bms-275291-01
- bms-275291-01
- d2163
- d2163
- d-2163
- n-((2s)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-l-leucyl-n,3- dimethyl-l-valinamide
- rebimastat
- rebimastat
- rebimastat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00036621 | Phase 2 | May 11, 2002 | Bristol-Myers Squibb |
| NCT00040755 | Phase 2 | May 1, 2002 | National Cancer Institute (NCI), University of California, Davis |
| NCT00039104 | Phase 2 | Apr 1, 2002 | Mayo Clinic, National Cancer Institute (NCI) |
| NCT00024024 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2001 | National Cancer Institute (NCI), Northwestern University |
| NCT00006229 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2000 | Canadian Cancer Trials Group, University of Alberta |
Showing 5 of 5 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Cancer Institute (NCI) | Government | 3 | 3 | 1 | 2001 |
| Bristol-Myers Squibb | For profit | 1 | 1 | 1 | 2002 |
| Canadian Cancer Trials Group | Academic/Hospital | 1 | 1 | 1 | 2000 |
| Mayo Clinic | Academic/Hospital | 1 | 0 | 1 | 2002 |
| Northwestern University | Academic/Hospital | 1 | 0 | 1 | 2001 |
| University of Alberta | Academic/Hospital | 1 | 0 | 1 | 2000 |
| University of California, Davis | Academic/Hospital | 1 | 0 | 1 | 2002 |
7 organizations
Page 1 / 1