refametinib
Small moleculeexperimental
Clinical trial activity
13 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
8
Phase 2
7
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2007 (NCT00610194)
Timeline
Indications
Mechanism of action
MAP2K2 inhibitor
Allosteric inhibitor
MAP2K1 inhibitor
Allosteric inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc(F)c(F)c(Nc2ccc(I)cc2F)c1NS(=O)(=O)C1(C[C@H](O)CO)CC1- Mol. weight
- 572.34 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1236682 ↗
- ChEMBLCHEMBL2138601 ↗
Also known as
- bay869766
- bay 869766
- bay-869766
- bay-86-9766
- bay-86-9766
- bay86-9766
- n-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide
- rdea119
- rdea119
- rdea119
- rdea 119
- rdea-119
- rdea-119
- rdea-119
- refametinib
- refametinib
- refametinib
- refametinib
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05754736 | Phase 2 | Dec 1, 2022 | Shandong first medical University |
| NCT02346032 | Phase 2 | Jun 30, 2015 | Sungkyunkwan University |
| NCT02168777 | Phase 1 | Jun 1, 2014 | Bayer |
| NCT01915602 | Phase 2 | Sep 27, 2013 | Bayer |
| NCT01915589 | Phase 2 | Sep 16, 2013 | Bayer |
| NCT01925638 | Phase 1 | Sep 1, 2013 | Bayer |
| NCT01764828 | Phase 1 | Feb 1, 2013 | Bayer |
| NCT01392521 | Phase 1 | Jul 1, 2011 | Bayer |
| NCT01251640 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2011 | Bayer |
| NCT01204177 | Phase 2 | Dec 1, 2010 | Bayer |
| NCT01179295 | Phase 1 | Nov 19, 2010 | Bayer |
| NCT00785226 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2008 | Bayer |
| NCT00610194 | Phase 1 | Nov 1, 2007 | Bayer |
Showing 13 of 13 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bayer | For profit | 11 | 11 | 2 | 2007 |
| Shandong first medical University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Sungkyunkwan University | Academic/Hospital | 1 | 1 | 1 | 2015 |
3 organizations
Page 1 / 1