OCTAMYLAMINE
Trade name: octinum
Small moleculeexperimental
Isometheptene (usually as isometheptene mucate) is a sympathomimetic amine sometimes used in the treatment of migraines and tension headaches due to its vasoconstricting properties. Isometheptene's vasoconstricting properties arise through activation of the sympathetic nervous system via epinephrine and norepinephrine. These compounds elicit smooth muscle activation leading to vasoconstriction by interacting with cell surface adrenergic receptors. — NCATS
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
1
Phase 4
0
Earliest trial started Nov 1, 2014 (NCT02290379)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
CNC(C)CCC=C(C)C- Mol. weight
- 141.2539 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- NCATSY7L24THH6T ↗
- ChEMBLCHEMBL2104792 ↗
- ChEMBLCHEMBL1697841 ↗
Also known as
- 6-methylamino-2-methylheptene
- isometeptene
- isomethepten
- isometheptene
- isometheptene
- isometheptene
- isometheptene
- isometheptene
- isometheptene
- isometheptene
- isometheptene
- isometheptene, (+-)-isomer
- isometheptene, maleate
- isometheptene, maleate(+-)-isomer
- isometheptene monohydrochoride
- isometheptene, monomaleate
- isometheptene, monomaleate(+-)-isomer
- isometheptene, monotartrate
- isometheptene mucate
- isometheptene mucate
- isometheptene mucate
- isometheptene, mucate (2:1)
- midrid
- midrid
- midrid
- n,1,5-trimethyl-4-hexenylamine
- n,6-dimethyl-5-hepten-2-amine
- octinum
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02706015 | Phase 3 | Oct 1, 2017 | Ache Laboratorios Farmaceuticos S.A. |
| NCT02290379 | Phase 1 | Nov 1, 2014 | Tonix Pharmaceuticals |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Ache Laboratorios Farmaceuticos S.A. | For profit | 1 | 1 | 1 | 2017 |
| Tonix Pharmaceuticals | For profit | 1 | 1 | 1 | 2014 |
2 organizations
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