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allogeneic pancreatic islet cells

Cell therapyexperimental

The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in 1869 by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1–2% of the pancreas volume and receive 10–15% of its blood flow. The pancreatic islets are arranged in density routes throughout the human pancreas, and are important in the metabolism of glucose. — Wikipedia

Clinical trial activity

60 trials · 48 clinical orgs · 0 marketing orgs

Phase 1
29
Phase 2
45
Phase 3
4
Phase 4
0

Earliest trial started Sep 1, 2000 (NCT00285233)

Timeline

2000s

  1. Jan 1, 2000

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2000

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2006

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

  • Unspecified targetTissue restoration

    tissue restoration

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • allogeneic islet cells
  • allogeneic islets of langerhans
  • allogeneic pancreatic islet cells
  • allogenic human islet cells
  • allogenic human purified pancreatic islets
  • allogenic islet cells
  • human islets
  • human pancreatic islet
  • human pancreatic islets
  • islet cells
  • islet of langerhans
  • islets of langerhans
  • pancreatic islets

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07118475Early Phase 1 (Phase 1)Aug 18, 2025Fudan University
NCT06651515Phase 1/Phase 2 (Phase 2)Jan 31, 2025Seraxis
NCT06751199N/ADec 30, 2024Second Military Medical University
NCT05990517Phase 2Feb 22, 2023Jiao Tong University
NCT05990530Phase 2Feb 22, 2023Jiao Tong University
NCT05480657Phase 1/Phase 2 (Phase 2)Sep 30, 2022Eledon Pharmaceuticals
NCT03977662Phase 1/Phase 2 (Phase 2)Jul 1, 2019California Institute for Regenerative Medicine (CIRM), University of California, San Francisco
NCT03746769Phase 1/Phase 2 (Phase 2)Feb 1, 2019City of Hope National Medical Center, University of California, Los Angeles
NCT03698396Phase 1/Phase 2 (Phase 2)Nov 1, 2018University of Virginia
NCT02846571Phase 1/Phase 2 (Phase 2)Jun 1, 2017Bascom Palmer Eye Institute, University of Miami
NCT02464878Phase 2Jan 1, 2017Harvard University, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Iowa
NCT02803905Phase 2Apr 1, 2016The Foundation Institute San Raffaele G. Giglio of Cefalù, Vita-Salute University of Milano. Italy
NCT02505893Phase 2Apr 1, 2015Fondazione Italiana Diabete Onlus, Vita-Salute University of Milano. Italy
NCT02402439Phase 1Dec 1, 2014University of California, San Francisco
NCT02213003Phase 1/Phase 2 (Phase 2)Sep 1, 2014Juvenile Diabetes Research Foundation, University of Miami
NCT01909245Phase 2Oct 1, 2013City of Hope National Medical Center, University of California, Los Angeles, Virginia Mason Medical Center
NCT02872571Phase 1/Phase 2 (Phase 2)Apr 1, 2013University of Lille
NCT01897688Phase 3Jun 1, 2012Northwestern University
NCT01722682Phase 1/Phase 2 (Phase 2)Jun 1, 2012Government of Italy, Vita-Salute University of Milano. Italy
NCT01606475N/AMay 23, 2012University of Minnesota
Showing 20 of 60 trials
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Organizations

Research & Development (48)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Government12142000
Juvenile Diabetes Research FoundationAcademic/Hospital9012000
National Institute of Allergy and Infectious Diseases (NIAID)Government9932001
University of MiamiAcademic/Hospital9632000
University of MinnesotaAcademic/Hospital7532000
National Institutes of Health (NIH)Government5022000
University of AlbertaAcademic/Hospital5222001
University of California, San FranciscoAcademic/Hospital5332006
City of Hope National Medical CenterAcademic/Hospital4422002
Baylor UniversityAcademic/Hospital3312005
Emory UniversityAcademic/Hospital3122002
Harvard UniversityAcademic/Hospital3222007
Northwestern UniversityAcademic/Hospital3122006
University of ChicagoAcademic/Hospital3322003
University of Illinois at ChicagoAcademic/Hospital3232004
Vita-Salute University of Milano. ItalyAcademic/Hospital3212012
Health Resources and Services Administration (HRSA)Government2012000
Jiao Tong UniversityAcademic/Hospital2212023
University of California, Los AngelesAcademic/Hospital2012013
University of LilleAcademic/Hospital2212003
48 organizations
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