prulifloxacin
Small moleculeexperimental
Prulifloxacin is an older synthetic antibiotic of the fluoroquinolone class undergoing clinical trials prior to a possible NDA submission to the U.S. Food and Drug Administration (FDA). It is a prodrug which is metabolized in the body to the active compound ulifloxacin. It was developed over two decades ago by Nippon Shinyaku Co. and was patented in Japan in 1987 and in the United States in 1989. — Wikipedia
Clinical trial activity
14 trials · 24 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
6
Phase 3
4
Phase 4
2
Earliest trial started Aug 1, 2006 (NCT00392574)
Timeline
Indications
Approved for
Mechanism of action
- DNA gyraseINHIBITOR
DNA gyrase inhibitor
- Topoisomerase IVINHIBITOR
Topoisomerase IV inhibitor
Broad spectrum antibiotic active against Gram-positive and Gram-negative bacteria.
- Bacterial DNA gyraseINHIBITOR
Bacterial DNA gyrase inhibitor
Broad spectrum antibiotic active against Gram-positive and Gram-negative bacteria.
Chemistry & pharmacology
Loading structure…
SMILES
Cc1oc(=O)oc1CN1CCN(c2cc3c(cc2F)c(=O)c(C(=O)O)c2n3C(C)S2)CC1- Mol. weight
- 461.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Prodrug
Sources
- WikipediaPrulifloxacin ↗
- ChEMBLCHEMBL422648 ↗
Also known as
- 1h,4h-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl)-1-piperazinyl)-4-oxo-
- 6-fluoro-1-methyl-7-(4-(5-methyl-2-oxo-1,3-dioxelen-4-yl)methyl-1-piperazinyl)-4-oxo-4h-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid
- nm441
- nm441
- nm 441
- nm-441
- prulifloxacin
- prulifloxacin
- prulifloxacin
- prulifloxacin
- prulifloxacin
- prulifloxacin
- prulifloxacin
- prulifloxacin
- sea buckthorn
- sea buckthorn oil
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02937298 | N/A | May 1, 2016 | University of Aberdeen |
| NCT03201796 | Phase 2 | Feb 2, 2016 | Angelini, Hippocrates Research |
| NCT02379169 | N/A | Feb 1, 2015 | Aromtech Ltd., University of Turku |
| NCT02439632 | Phase 3 | Feb 1, 2014 | Lee's Pharmaceutical |
| NCT02157571 | Phase 3 | Jun 1, 2013 | Lee's Pharmaceutical |
| NCT01697085 | N/A | Oct 1, 2012 | Aromtech Ltd., The Finnish Funding Agency for Technology and Innovation, University of Turku |
| NCT02130713 | Phase 4 | Jan 1, 2012 | University of Roma La Sapienza |
| NCT01231737 | Phase 2 | Nov 1, 2010 | University of Perugia |
| NCT01710488 | Phase 4 | May 1, 2009 | Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) Foundation |
| NCT00767156 | N/A | Oct 1, 2008 | Aromtech Ltd., Institute of Skin and Product Evaluation, Italy |
| NCT00739713 | N/A | Sep 1, 2008 | Aromtech Ltd., Finnsusp Ltd., The Finnish Funding Agency for Technology and Innovation, Turku Municipal Health Department/evo-funding, University of Turku, Valioravinto Ltd |
| NCT01860547 | N/A | Jun 1, 2008 | Aromtech Ltd., Fazer Bakeries Ltd., Finnish Berry Powders Ltd., Kiantama Ltd., Pakkasmarja Ltd., Saarioinen Ltd., Satakunta Sea Buckthorn Society, University of Turku |
| NCT00448422 | Phase 3 | Dec 1, 2006 | Optimer Pharmaceuticals, University of Zurich |
| NCT00392574 | Phase 3 | Aug 1, 2006 | Merck, The University of Texas, Dallas |
Showing 14 of 14 trials
Page 1 / 1
Organizations
Research & Development (24)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Aromtech Ltd. | For profit | 5 | 1 | 1 | 2008 |
| University of Turku | Academic/Hospital | 4 | 3 | 1 | 2008 |
| Lee's Pharmaceutical | For profit | 2 | 2 | 1 | 2013 |
| The Finnish Funding Agency for Technology and Innovation | Government | 2 | 0 | 1 | 2008 |
| Angelini | For profit | 1 | 1 | 1 | 2016 |
| Fazer Bakeries Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) Foundation | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Finnish Berry Powders Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Finnsusp Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Hippocrates Research | For profit | 1 | 0 | 1 | 2016 |
| Institute of Skin and Product Evaluation, Italy | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Kiantama Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Merck | For profit | 1 | 1 | 1 | 2006 |
| Optimer Pharmaceuticals | For profit | 1 | 1 | 1 | 2006 |
| Pakkasmarja Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Saarioinen Ltd. | For profit | 1 | 0 | 1 | 2008 |
| Satakunta Sea Buckthorn Society | Academic/Hospital | 1 | 0 | 1 | 2008 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Turku Municipal Health Department/evo-funding | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Aberdeen | Academic/Hospital | 1 | 1 | 1 | 2016 |
24 organizations
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