CDEK by Data4ThePeople
Sign in Sign up
← All drugs Report issue

procalcitonin

Small moleculeexperimental

Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It arises once preprocalcitonin is cleaved by endopeptidase. It was first identified by Leonard J. Deftos and Bernard A. Roos in the 1970s. It is composed of 116 amino acids and is produced by parafollicular cells of the thyroid and by the neuroendocrine cells of the lung and the intestine. — Wikipedia

Clinical trial activity

9 trials · 25 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
0

Earliest trial started Nov 1, 2009 (NCT00832039)

Timeline

2000s

  1. Jan 1, 2009

    Earliest Phase 3 Sponsor(trial)

Indications

Studied for

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C
Mol. weight
3475.94 g/mol
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • procalcitonin
  • procalcitonin

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02392689N/AMar 31, 2015Brahms AG
NCT02202941N/AAug 31, 2014Seoul National University, Sungkyunkwan University, University of Ulsan, Yonsei University
NCT03058718N/AJan 1, 2014Shandong University
NCT01977079N/ADec 31, 2013Centre Hospitalier Departemental Vendee
NCT01847079N/AJan 31, 2013Erasmus University Rotterdam
NCT02173613N/AAug 31, 2012University of Grenoble
NCT00928291N/AJan 1, 2010Federal University of Minas Gerais
NCT01139489N/ANov 30, 2009Atrium Medical Center, Bronovo Hospital, Canisius-Wilhelmina Hospital, Dijklander Ziekenhuis, Elisabeth-TweeSteden Ziekenhuis, Free University of Amsterdam, Isala Clinics, Zwolle, The Netherlands, Medical Center Haaglanden, Medisch Spectrum Twente, Slotervaart Hospital, University of Groningen, Utrecht University
NCT00832039Phase 3Nov 1, 2009Biosyn, Brahms AG, Friedrich Schiller University, Sepsis Foundation
Showing 9 of 9 trials
Page 1 / 1

Organizations

Research & Development (25)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Brahms AGFor profit2122009
Atrium Medical CenterAcademic/Hospital1012009
BiosynFor profit1012009
Bronovo HospitalAcademic/Hospital1012009
Canisius-Wilhelmina HospitalAcademic/Hospital1012009
Centre Hospitalier Departemental VendeeAcademic/Hospital1112013
Dijklander ZiekenhuisAcademic/Hospital1012009
Elisabeth-TweeSteden ZiekenhuisAcademic/Hospital1012009
Erasmus University RotterdamAcademic/Hospital1112013
Federal University of Minas GeraisAcademic/Hospital1112010
Free University of AmsterdamAcademic/Hospital1112009
Friedrich Schiller UniversityAcademic/Hospital1012009
Isala Clinics, Zwolle, The NetherlandsAcademic/Hospital1012009
Medical Center HaaglandenAcademic/Hospital1012009
Medisch Spectrum TwenteAcademic/Hospital1012009
Seoul National UniversityAcademic/Hospital1112014
Sepsis FoundationAcademic/Hospital1112009
Shandong UniversityAcademic/Hospital1112014
Slotervaart HospitalAcademic/Hospital1012009
Sungkyunkwan UniversityAcademic/Hospital1012014
25 organizations
Page 1 / 2