pridopidine

Small moleculeexperimental

Pridopidine is an orally administrated small molecule investigational drug. Pridopidine is a selective and potent Sigma-1 Receptor agonist. It is being developed by Prilenia Therapeutics and is currently in late-stage clinical development for Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). — Wikipedia

Clinical trial activity

10 trials · 9 clinical orgs · 0 marketing orgs

Phase 1
1
Phase 2
6
Phase 3
4
Phase 4
0

Earliest trial started Apr 1, 2008 (NCT00665223)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Jan 1, 2017

    Earliest Phase 1 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCCN1CCC(c2cccc(S(C)(=O)=O)c2)CC1
Mol. weight
281.42 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 4-(3-methanesulfonylphenyl)-1-propylpiperidine
  • 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine
  • acr16
  • acr16
  • acr16
  • acr16 compound
  • fr-310826
  • fr-310826
  • huntexil
  • pridopidine
  • pridopidine
  • pridopidine
  • pridopidine
  • pridopidine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT04615923Phase 2/Phase 3 (Phase 3)Dec 18, 2020Harvard University, Prilenia
NCT04556656Phase 3Oct 16, 2020Prilenia
NCT03922711Phase 2Mar 26, 2019Prilenia
NCT03019289Phase 1Mar 20, 2017Teva
NCT02494778Phase 2Sep 30, 2015Teva
NCT02006472Phase 2Feb 1, 2014European Huntington's Disease Network, Huntington Study Group, Teva
NCT01306929Phase 2Mar 1, 2011Teva, University of Rochester
NCT00724048Phase 2/Phase 3 (Phase 3)Oct 1, 2008NeuroSearch A/S, Teva
NCT00665223Phase 3Apr 1, 2008Teva
NCT06069934N/AHarvard University, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Prilenia
Showing 10 of 10 trials
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Organizations

Research & Development (9)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
TevaFor profit6632008
PrileniaFor profit4332019
Harvard UniversityAcademic/Hospital2122020
European Huntington's Disease NetworkAcademic/Hospital1012014
Huntington Study GroupAcademic/Hospital1012014
National Institute of Neurological Disorders and Stroke (NINDS)Government101
National Institutes of Health (NIH)Government101
NeuroSearch A/SFor profit1012008
University of RochesterAcademic/Hospital1012011
9 organizations
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