polaprezinc

Small moleculeexperimental

Zinc L-carnosine, often simply called zinc carnosine, and also known as polaprezinc, is a mucosal protective chelate compound of zinc and L-carnosine invented by Hamari Chemicals, Ltd. It is a quadridentate 1:1 complex of a polymeric nature. Although it contains 23% zinc and 77% L-carnosine by mass, zinc carnosine is a molecule and not a mixture of zinc and L-carnosine. — Wikipedia

Clinical trial activity

4 trials · 6 clinical orgs · 0 marketing orgs

Phase 1
2
Phase 2
2
Phase 3
1
Phase 4
0

Earliest trial started May 1, 2005 (NCT00149149)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2020

    Earliest Phase 3 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetAntioxidant

    antioxidant

Chemistry & pharmacology

Loading structure…

SMILES

NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Mol. weight
226.24 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • ahz-zinc
  • beta-alanyl-l-histidinato zinc
  • beta-alanyl-l-histidinato zinc
  • beta-alanyl-l-histidinato zinc
  • n-(3-aminopropionyl)-l-histidinato zinc
  • polaprezinc
  • polaprezinc
  • polaprezinc
  • polaprezinc
  • polaprezinc
  • z 103
  • z-103
  • zinc carnosine
  • zinc carnosine
  • zinc carnosine
  • zinc l-carnosine
  • zinc l-carnosine
  • zinc l-carnosine
  • zinc l-carnosine
  • zinc l-carnosine complex
  • zinc n-(3-aminopropionyl)histidine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT05549778Phase 1/Phase 2 (Phase 2)Jan 6, 2021Jiangnan University
NCT04430998Phase 3Jun 30, 2020Azienda Farmaceutica Italiana s.r.l., University of Milan
NCT02243618N/ASep 1, 2014Yonsei University
NCT00149149Phase 1May 1, 2005University of London, Wexham GI Trust
Showing 4 of 4 trials
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Organizations

Research & Development (6)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Azienda Farmaceutica Italiana s.r.l.Academic/Hospital1012020
Jiangnan UniversityAcademic/Hospital1112021
University of LondonAcademic/Hospital1112005
University of MilanAcademic/Hospital1112020
Wexham GI TrustAcademic/Hospital1012005
Yonsei UniversityAcademic/Hospital1112014
6 organizations
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