piperacetazine
Trade name: quide
Small moleculeapproved
Approved
Feb 3, 1969
Piperacetazine (Quide) is an antipsychotic prodrug, most notably used for schizophrenia. The study indicates that Quide is a useful addition to the armamentarium of the physician faced with the difficult problem of treating the chronic hospitalized patient with a schizophrenic illness. Side effects of the drug were generally mild, and there was no evidence that it would produce blood dyscrasias or liver impairment. — NCATS
Clinical trial activity
3 trials · 3 clinical orgs · 2 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Nov 1, 2012 (NCT01774045)
Timeline
1960s
- Feb 3, 1969
Earliest FDA Approval
- Feb 3, 1969
Dow Pharmaceutical Sciences — NDA Secondary Org
Indications
Approved for
Mechanism of action
- Dopamine D2 receptorANTAGONIST
Dopamine D2 receptor antagonist
- Unspecified targetOTHER
Unknown
Approval history
- approvedFeb 3, 1969
Chemistry & pharmacology
Loading structure…
SMILES
CC(=O)C1=CC=C2SC3=CC=CC=C3N(CCCN4CCC(CCO)CC4)C2=C1- Mol. weight
- 410.572 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Discontinued
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaPiperacetazine ↗
- NCATSKL6248WNW4 ↗
- ChEMBLCHEMBL1584 ↗
Also known as
- pc-1421
- pc-1421
- pdc-1421
- piperacetazine
- piperacetazine
- piperacetazine
- piperacetazine
- piperacetazine
- piperacetazine
- piperacetazine
- piperacetazine
- psymod
- quide
- quide
- quide
- quide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02699086 | Phase 2 | Dec 1, 2017 | BioLite, Inc. |
| NCT02395978 | Phase 2 | Mar 1, 2015 | BioLite, Inc., Taipei Medical University |
| NCT01774045 | Phase 1 | Nov 1, 2012 | BioLite, Inc., Taipei Veteran General hospital |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BioLite, Inc. | For profit | 3 | 3 | 2 | 2012 |
| Taipei Medical University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Taipei Veteran General hospital | Government | 1 | 0 | 1 | 2012 |
3 organizations
Page 1 / 1
Marketing (2)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Dow Pharmaceutical Sciences | For profit | NDA2 | Feb 3, 1969 |
| Richardson Vicks Inc | For profit | NDA | — |