arformoterol
Trade name: brovana
Approved
Oct 6, 2006
Arformoterol, sold under the brand name Brovana among others, is a medication used for the treatment of chronic obstructive pulmonary disease (COPD). — Wikipedia
Clinical trial activity
22 trials · 13 clinical orgs · 19 marketing orgs
Earliest trial started Feb 1, 2002 (NCT00685841)
Timeline
2000s
2010s
- Aug 5, 2016
Teva — Marketing Organization
2020s
- Jun 22, 2021
BE Pharmaceuticals — Marketing Organization
- Jun 22, 2021
Axar Pharma Inc — Marketing Organization
- Jun 22, 2021
Cipla — Marketing Organization
- Jun 22, 2021
Glenmark Pharmaceuticals — Marketing Organization
- Jun 22, 2021
SLATE RUN PHARMA — Marketing Organization
- Mar 2, 2022
Ritedose — Marketing Organization
- Mar 2, 2022
Yichang Humanwell Pharmaceutical Co.,Ltd — Marketing Organization
- May 10, 2022
Alembic — Marketing Organization
- May 26, 2022
Sun Pharmaceuticals — Marketing Organization
- Nov 15, 2022
Mankind Pharma — Marketing Organization
- Nov 28, 2022
Wilshire Pharmaceuticals — Marketing Organization
- Nov 28, 2022
Slayback Pharma Llc — Marketing Organization
- Apr 2, 2024
AiPing Pharm Inc — Marketing Organization
- May 17, 2024
CF PHARMTECH — Marketing Organization
- Jun 3, 2024
Dr. Reddy's Laboratories — Marketing Organization
- Nov 18, 2024
LEXENPHARM — Marketing Organization
- Jan 1, 2025
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Beta-2 adrenergic receptorAGONIST
ADRB2 agonist
Long acting
Approval history
- approvedOct 6, 2006
Chemistry & pharmacology
SMILES
COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1- Mol. weight
- 344.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
Sources
- ChEMBLCHEMBL1363 ↗
- WikipediaArformoterol ↗
- ChEMBLCHEMBL1951071 ↗
- NCATSF91H02EBWT ↗
- NCATS5ZZ84GCW8B ↗
Also known as
- aformoterol
- aformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol
- arformoterol tartrate
- arformoterol tartrate
- arformoterol tartrate
- arformoterol tartrate
- arformoterol tartrate
- brovana
- brovana
- brovana
- brovanda
- (-)-formoterol
- (-)-formoterol
- (r,r)-formoterol
- (r,r)-formoterol
- sunpharma1505
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06922383 | Phase 1/Phase 2 (Phase 2) | Apr 10, 2025 | Humboldt University, Isofol Medical AB |
| NCT05055414 | Phase 2 | Nov 1, 2021 | Korea United Pharm. Inc. |
| NCT03219866 | Phase 4 | Oct 3, 2017 | Wake Forest University |
| NCT02534896 | Phase 3 | Nov 1, 2015 | Sun Pharmaceuticals |
| NCT02275481 | Phase 4 | Nov 1, 2014 | Sunovion |
| NCT01391559 | N/A | Jul 1, 2011 | Dartmouth University, Sunovion |
| NCT01361984 | Phase 4 | Jun 1, 2011 | Sunovion, University of California, Los Angeles |
| NCT00909779 | Phase 3 | Jun 1, 2009 | Sunovion |
| NCT00819637 | Phase 4 | Jan 1, 2009 | Henry Ford Health System, Sunovion |
| NCT00846287 | N/A | Nov 1, 2008 | University of Massachusetts |
| NCT00773786 | Phase 4 | Oct 1, 2008 | Saint Francis Hospital and Medical Center, Sunovion |
| NCT00754546 | Phase 4 | Aug 1, 2008 | Dartmouth University, Sunovion |
| NCT00662779 | Phase 3 | Apr 1, 2008 | University of New Mexico |
| NCT00583947 | Phase 2 | Jan 1, 2008 | Sunovion, Unicon Pharma |
| NCT00571428 | Phase 4 | Nov 1, 2007 | Sunovion |
| NCT00424528 | Phase 4 | Dec 1, 2006 | Sunovion |
| NCT00250679 | Phase 3 | Oct 1, 2005 | Sunovion |
| NCT00685529 | Phase 2 | Apr 1, 2005 | Sunovion |
| NCT00691405 | Phase 2 | Oct 1, 2003 | Sunovion |
| NCT00064415 | Phase 3 | Jun 1, 2002 | Sunovion |
Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sunovion | For profit | 16 | 11 | 4 | 2002 |
| Dartmouth University | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Henry Ford Health System | Academic/Hospital | 1 | 1 | 1 | 2009 |
| Humboldt University | Academic/Hospital | 1 | 0 | 1 | 2025 |
| Isofol Medical AB | For profit | 1 | 1 | 1 | 2025 |
| Korea United Pharm. Inc. | For profit | 1 | 1 | 1 | 2021 |
| Saint Francis Hospital and Medical Center | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Sun Pharmaceuticals | For profit | 1 | 1 | 1 | 2015 |
| Unicon Pharma | For profit | 1 | 0 | 1 | 2008 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Massachusetts | Academic/Hospital | 1 | 1 | 1 | 2008 |
| University of New Mexico | Academic/Hospital | 1 | 1 | 1 | 2008 |
| Wake Forest University | Academic/Hospital | 1 | 1 | 1 | 2017 |
Marketing (22)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| AiPing Pharm Inc | For profit | MKTG | Apr 2, 2024 |
| Alembic | For profit | MKTG | May 10, 2022 |
| Axar Pharma Inc | For profit | MKTG | Feb 3, 2021 |
| Axar Pharma Inc | For profit | MKTG | Jun 22, 2021 |
| BE Pharmaceuticals | For profit | MKTG | Jun 22, 2021 |
| CF PHARMTECH | For profit | MKTG | May 17, 2024 |
| Cipla | For profit | MKTG | Jun 22, 2021 |
| Dr. Reddy's Laboratories | For profit | MKTG | Jun 3, 2024 |
| Glenmark Pharmaceuticals | For profit | MKTG | Jun 22, 2021 |
| LEXENPHARM | For profit | MKTG | Nov 18, 2024 |
| Lupin | For profit | MKTG | Oct 6, 2006 |
| Lupin | For profit | NDA2 | Oct 6, 2006 |
| Mankind Pharma | For profit | MKTG | Nov 15, 2022 |
| Ritedose | For profit | MKTG | Mar 2, 2022 |
| SLATE RUN PHARMA | For profit | MKTG | Jun 22, 2021 |
| Slayback Pharma Llc | For profit | MKTG | Nov 28, 2022 |
| Sun Pharmaceuticals | For profit | MKTG | May 26, 2022 |
| Sunovion | For profit | NDA2 | Oct 6, 2006 |
| Sunovion | For profit | NDA | Oct 6, 2006 |
| Teva | For profit | MKTG | Aug 5, 2016 |
| Wilshire Pharmaceuticals | For profit | MKTG | Nov 28, 2022 |
| Yichang Humanwell Pharmaceutical Co.,Ltd | For profit | MKTG | Mar 2, 2022 |