ortataxel
Small moleculeexperimental
Ortataxel is a drug used in chemotherapy. As of June 2009, Spectrum Pharmaceuticals has the drug in a Phase 2 clinical trial. — Wikipedia
Clinical trial activity
8 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
8
Phase 3
0
Phase 4
0
Earliest trial started Dec 1, 2001 (NCT00044538)
Timeline
2000s
- Jan 1, 2001
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
Chemistry & pharmacology
Loading structure…
SMILES
CCOc1ncc(C)c2c1[C@H](c1ccc(C#N)cc1OC)C(C(N)=O)=C(C)N2- Mol. weight
- 378.43 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
- Availability
- Prescription Only
Oral
Yes
Parenteral
No
Topical
No
First in class
Sources
- WikipediaOrtataxel ↗
- ChEMBLCHEMBL382300 ↗
- ChEMBLCHEMBL2181927 ↗
Also known as
- 13-(n-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxy-baccatin-1,14-carbonate
- 13-(n-tert-butoxycarbonyl-beta-isobutyisoserinyl)-14-hydroxybaccatin-1,14-carbonate
- bay 59-8862
- bay 59-8862
- bay 59-8862
- bay-59-8862
- bay59-8862
- bay59-8862
- bay59-8862
- bay 94-8862
- bay 94-8862
- bay 94-8862
- bay94-8862
- bay94-8862
- idn 5109
- ind5109
- ortataxel
- ortataxel
- ortataxel
- ortataxel
- ortataxel
- sb-t-101131
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01989884 | Phase 2 | Nov 1, 2013 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Mario Negri Institute |
| NCT01968668 | Phase 2 | Oct 1, 2013 | Bayer |
| NCT00044525 | Phase 2 | Apr 1, 2002 | Bayer |
| NCT00054314 | Phase 2 | Mar 1, 2002 | National Cancer Institute (NCI), State University of New York, Buffalo |
| NCT00039156 | Phase 2 | Jan 1, 2002 | Theradex, Yeshiva University |
| NCT00044564 | Phase 2 | Dec 1, 2001 | Bayer |
| NCT00044538 | Phase 2 | Dec 1, 2001 | Bayer |
| NCT00039169 | Phase 2 | Dec 1, 2001 | Theradex |
Showing 8 of 8 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bayer | For profit | 4 | 4 | 1 | 2001 |
| Theradex | For profit | 2 | 2 | 1 | 2001 |
| Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Mario Negri Institute | Academic/Hospital | 1 | 1 | 1 | 2013 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2002 |
| State University of New York, Buffalo | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Yeshiva University | Academic/Hospital | 1 | 0 | 1 | 2002 |
7 organizations
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