oltipraz
Small moleculeexperimental
Oltipraz is an organosulfur compound belonging to the dithiolethione class. It acts as a schistosomicide and has been shown in rodent models to inhibit the formation of cancers in the bladder, blood, colon, kidney, liver, lung, pancreas, stomach, and trachea, skin, and mammary tissue. Clinical trials of oltipraz have failed to demonstrate efficacy and have shown significant side effects, including neurotoxicity and gastrointestinal toxicity. Oltipraz has also been shown to generate superoxide radicals, which can be toxic. — Wikipedia
Clinical trial activity
5 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
4
Phase 3
2
Phase 4
0
Earliest trial started Aug 1, 2000 (NCT00006457)
Timeline
Indications
Mechanism of action
PRKAB1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cc1c(-c2cnccn2)ssc1=S- Mol. weight
- 226.35 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaOltipraz ↗
- ChEMBLCHEMBL178459 ↗
Also known as
- 35 972 r.p.
- 3h-1,2-dithiole-3-thione, 4-methyl-5-pyrazinyl-
- 4-methyl-5-pyrazinyl-3h-1,2-dithiole-3-thione
- 4-methyl-pdt
- 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione
- oltipraz
- oltipraz
- oltipraz
- oltipraz
- oltipraz
- rp 35972
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04142749 | Phase 3 | Oct 31, 2019 | PharmaKing, Seoul National University |
| NCT02068339 | Phase 3 | Feb 1, 2014 | PharmaKing |
| NCT01373554 | Phase 2 | May 1, 2011 | PharmaKing, Seoul National University |
| NCT00956098 | Phase 2 | Feb 1, 2006 | CJ HealthCare Corp. |
| NCT00006457 | Phase 1 | Aug 1, 2000 | National Cancer Institute (NCI), Northwestern University |
Showing 5 of 5 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| PharmaKing | For profit | 3 | 3 | 2 | 2011 |
| Seoul National University | Academic/Hospital | 2 | 0 | 2 | 2011 |
| CJ HealthCare Corp. | For profit | 1 | 1 | 1 | 2006 |
| National Cancer Institute (NCI) | Government | 1 | 0 | 1 | 2000 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2000 |
5 organizations
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