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oleic acid

Small moleculeexperimental

Oleic acid is an unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. Oleic acid occurs naturally in various animal and vegetable fats and oils. It is a component of the normal human diet as a part of animal fats and vegetable oils. Oleic acid may be responsible for the hypotensive (blood pressure reducing) effects of olive oil. Oleic acid has being shown to have a potential anticancer activity. — NCATS

Clinical trial activity

23 trials · 37 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
3
Phase 3
0
Phase 4
1

Earliest trial started Sep 1, 2000 (NCT00059254)

Timeline

2000s

  1. Jan 1, 2000

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetSupplementation

    supplementation

Chemistry & pharmacology

Loading structure…

SMILES

CCCCCCCC\C=C/CCCCCCCC(O)=O
Mol. weight
282.4614 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Achiral Molecule
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 9z-octadecenoic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • oleic acid
  • osteum
  • sodium oleate
  • sodium oleate
  • sodium oleate
  • suet
  • suet

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07027033N/AJul 1, 2025University of Nantes
NCT04531410N/AJul 1, 2021European Society of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska Institute, Poznan University, University of Milan, University of Oslo
NCT03739463N/ADec 3, 2018Laval University, University of Sherbrooke
NCT03372733Phase 2Jul 31, 2018National Heart, Lung, and Blood Institute (NHLBI)
NCT02841618N/AJan 31, 2016Ohio State University
NCT02540759Phase 1Sep 1, 2015Réseau de Santé Vitalité Health Network
NCT02091583N/ANov 1, 2014Agriculture and Agri-Food Canada, Canadian Institutes of Health Research (CIHR), University of Manitoba
NCT03054779N/ASep 30, 2014Canola Council of Canada, Laval University, Pennsylvania State University, Unity Health Toronto, University of Manitoba
NCT02243969N/AMay 1, 2014Maastricht University, Unilever
NCT02029833N/AMar 31, 2013Agriculture and Agri-Food Canada, Canola Council of Canada, Laval University, Pennsylvania State University, University at Buffalo, University of Manitoba, University of Toronto
NCT01661764Phase 2Feb 4, 2013National Cancer Institute (NCI), Vanderbilt University
NCT03149653Phase 4Jan 15, 2012Charles University, Government of Czech Republic
NCT01250275N/ASep 30, 2011University of Manitoba
NCT01365078N/AJul 1, 2011Bioriginal, Maastricht University
NCT01233778N/AOct 1, 2010Pennsylvania State University, University of Manitoba
NCT01351012N/ASep 30, 2010Laval University, Pennsylvania State University, University of Manitoba, University of Toronto
NCT01066091N/AMar 31, 2010Government of France, Institut technique d'études et de recherches des corps gras, University Clermont Auvergne
NCT00909012N/AMay 1, 2009European Union, Ludwig Maximilians University
NCT00638196Phase 1Mar 1, 2008University of Rochester
NCT00927199Phase 2Sep 1, 2007Agri-Food Research and Development Initiative, Canola Council of Canada, Flax Canada 2015 Inc., University of Manitoba
Showing 20 of 23 trials
Page 1 / 2

Organizations

Research & Development (37)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of ManitobaAcademic/Hospital7522007
Laval UniversityAcademic/Hospital4012010
Pennsylvania State UniversityAcademic/Hospital4212010
Canola Council of CanadaAcademic/Hospital3022007
Agriculture and Agri-Food CanadaGovernment2012013
Karolinska InstituteAcademic/Hospital2212005
Maastricht UniversityAcademic/Hospital2212011
University of TorontoAcademic/Hospital2012010
Agri-Food Research and Development InitiativeAcademic/Hospital1012007
BioriginalFor profit1012011
Canadian Institutes of Health Research (CIHR)Academic/Hospital1012014
Charles UniversityAcademic/Hospital1112012
European Society of Pediatric Gastroenterology, Hepatology and NutritionAcademic/Hospital1012021
European UnionGovernment1012009
Flax Canada 2015 Inc.Academic/Hospital1012007
Government of Czech RepublicGovernment1012012
Government of FranceGovernment1112010
Institut technique d'études et de recherches des corps grasAcademic/Hospital1012010
Ludwig Maximilians UniversityAcademic/Hospital1112009
National Cancer Institute (NCI)Government1012013
37 organizations
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