nefopam
Trade name: Acupan
Small moleculeexperimental
Nefopam, sold under the brand name Acupan among others, is a centrally acting, non-opioid painkilling medication, with central stimulant and sympathomimetic properties that is primarily used to treat moderate to severe pain. — Wikipedia
Clinical trial activity
45 trials · 36 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
12
Phase 3
11
Phase 4
7
Earliest trial started Aug 1, 2004 (NCT03122665)
Timeline
Indications
Approved for
Studied for
- Acute Pain · Phase 3
- Analgesia · Phase 3
- Analgesics, Opioid · Phase 3
- Anesthesia · Phase 2/Phase 3
- Arthroplasty, Replacement, Hip · Phase 3
- Burns · Phase 2
- Cholecystectomy · Phase 3
- Cholecystitis · Phase 4
- Chronic Pain · Phase 2/Phase 3
- Cicatrix · Phase 1
- Critical Illness · Phase 3
- Drug-Related Side Effects and Adverse Reactions · Phase 4
- Dyspnea · Phase 3
- General Surgery · Phase 4
- Healthy Volunteers · Phase 1
- HIV Infections · Phase 2
- Hyperalgesia · Phase 2/Phase 3
- Laparotomy · Phase 2/Phase 3
- Lung Neoplasms · Phase 2
- Nefopam · Phase 3
- Pain · Phase 3
- Pain Management · Early Phase 1
- Pancreatitis · Phase 3
- Postoperative Pain · Phase 4
- Procedural Sedation · Phase 3
- Renal Colic · Phase 4
- Respiration, Artificial · Phase 3
- Shivering · Phase 4
- Stomach Neoplasms · Phase 3
- Tendon Injuries · Phase 4
- Ureteral Diseases · Phase 4
- Wound Infection · Phase 2/Phase 3
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
CN1CCOC(c2ccccc2)c2ccccc2C1- Mol. weight
- 253.35 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL465026 ↗
- WikipediaNefopam ↗
- ChEMBLCHEMBL1407915 ↗
Also known as
- acupan
- acupan
- acupan
- fenazoxine
- nefopam
- nefopam
- nefopam
- nefopam
- nefopam
- nefopam
- nefopam
- nefopam
- (+/-)-nefopam
- nefopam hcl
- nefopam hcl
- nefopam hcl
- nefopam hydrochloride
- nefopam hydrochloride
- nefopam hydrochloride
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06627816 | N/A | Oct 31, 2024 | Cairo University |
| NCT06349798 | Phase 3 | Apr 30, 2024 | University Hospital, Tours |
| NCT06680609 | Early Phase 1 (Phase 1) | Jun 1, 2023 | Jordan University, King Abdullah Medical City |
| NCT05861791 | N/A | Feb 7, 2023 | Chung-Ang University |
| NCT05648058 | Phase 3 | Dec 20, 2022 | Government of Iraq |
| NCT05173337 | N/A | Dec 8, 2021 | Kangbuk Samsung Hospital |
| NCT05129137 | Phase 1 | Nov 15, 2021 | Accutest Research Laboratories (I) Pvt. Ltd., Unither Pharmaceuticals |
| NCT05071352 | Phase 3 | Oct 31, 2021 | Cairo University |
| NCT04685577 | Phase 2 | Jan 31, 2021 | University of Alberta |
| NCT04622813 | Phase 3 | Dec 31, 2020 | American University of Beirut |
| NCT04870541 | Phase 4 | Dec 1, 2020 | Saint-Joseph University |
| NCT04622735 | Phase 3 | Nov 30, 2020 | EXCELYA, Unither Pharmaceuticals, University of Birmingham |
| NCT04576078 | Phase 2 | Oct 31, 2020 | Hopital de la Croix Rousse, University of Lyon |
| NCT04241640 | Phase 4 | Jul 31, 2020 | Mahidol University |
| NCT04450355 | N/A | Jul 1, 2020 | Pharmbio Korea, Seoul National University |
| NCT03955705 | N/A | May 31, 2019 | Mahidol University |
| NCT03462836 | N/A | Apr 1, 2018 | Yonsei University |
| NCT02441673 | Phase 2 | Oct 1, 2017 | Lagos State Health Service Commission |
| NCT04110665 | Phase 4 | Sep 1, 2017 | Centre Hospitalier Universitaire de Nīmes |
| NCT03036306 | Phase 1 | Jan 1, 2017 | ScarX Corp |
Showing 20 of 45 trials
Page 1 / 3
Organizations
Research & Development (36)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Seoul National University | Academic/Hospital | 7 | 7 | 3 | 2012 |
| Yonsei University | Academic/Hospital | 7 | 7 | 2 | 2012 |
| Pharmbio Korea | For profit | 3 | 0 | 3 | 2012 |
| University Clermont Auvergne | Academic/Hospital | 3 | 3 | 3 | 2008 |
| Cairo University | Academic/Hospital | 2 | 2 | 2 | 2021 |
| Centre Hospitalier Universitaire de Nīmes | Academic/Hospital | 2 | 2 | 2 | 2011 |
| Mahidol University | Academic/Hospital | 2 | 2 | 2 | 2019 |
| Unither Pharmaceuticals | For profit | 2 | 2 | 2 | 2020 |
| Accutest Research Laboratories (I) Pvt. Ltd. | For profit | 1 | 0 | 1 | 2021 |
| American University of Beirut | Academic/Hospital | 1 | 1 | 1 | 2020 |
| Biocodex | For profit | 1 | 0 | 1 | 2004 |
| Biokinetic Europe Ltd | For profit | 1 | 0 | 1 | 2015 |
| Catholic University of Korea | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Chung-Ang University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| EXCELYA | For profit | 1 | 0 | 1 | 2020 |
| Galen | For profit | 1 | 1 | 1 | 2015 |
| Government of Iraq | Government | 1 | 1 | 1 | 2022 |
| Hallym University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Hopital de la Croix Rousse | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Jordan University | Academic/Hospital | 1 | 0 | 1 | 2023 |
36 organizations
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