neramexane
Small moleculeexperimental
Neramexane is a drug related to memantine, which acts as an NMDA antagonist and has neuroprotective effects. It is being developed for various possible applications, including treatment of tinnitus, Alzheimer's disease, drug addiction and as an analgesic. Animal studies have also suggested antidepressant and nootropic actions so that this drug may be used for a wide range of potential applications. It also acts as a nicotinic acetylcholine receptor antagonist. — Wikipedia
Clinical trial activity
9 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
7
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Mar 1, 2003 (NCT00090116)
Timeline
Indications
Mechanism of action
- Glutamate [NMDA] receptor subunit 3AANTAGONIST
GRIN3A antagonist
Chemistry & pharmacology
Loading structure…
SMILES
CC1(C)CC(C)(C)CC(C)(N)C1- Mol. weight
- 169.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- Yes
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaNeramexane ↗
- ChEMBLCHEMBL2110954 ↗
Also known as
- 1-amino-1,3,3,5,5-pentamethylcyclohexane hydrochloride
- mrz 2579
- mrz 2 579
- mrz 2-579
- mrz-2579
- neramexane
- neramexane
- neramexane
- neramexane
- neramexane
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01109680 | Phase 1 | Apr 1, 2010 | Merz |
| NCT00972127 | Phase 1 | Oct 1, 2009 | Merz |
| NCT00983099 | Phase 1 | Sep 1, 2009 | Merz |
| NCT00978614 | Phase 1 | Sep 1, 2009 | Merz |
| NCT00955760 | Phase 1 | Aug 1, 2009 | Merz |
| NCT00936026 | Phase 1 | Jul 1, 2009 | Merz |
| NCT00915174 | Phase 1 | Jun 1, 2009 | Merz |
| NCT00405886 | Phase 2 | Oct 1, 2005 | Ludwig Maximilians University, Merz |
| NCT00090116 | Phase 3 | Mar 1, 2003 | Forest Laboratories |
Showing 9 of 9 trials
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Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merz | For profit | 8 | 8 | 2 | 2005 |
| Forest Laboratories | For profit | 1 | 1 | 1 | 2003 |
| Ludwig Maximilians University | Academic/Hospital | 1 | 0 | 1 | 2005 |
3 organizations
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