naftopil
Trade name: Flivas
Small moleculeexperimental
Clinical trial activity
7 trials · 15 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
3
Phase 3
3
Phase 4
3
Earliest trial started Sep 1, 2009 (NCT00967772)
Timeline
Indications
Approved for
Mechanism of action
- Alpha-1d adrenergic receptorANTAGONIST
Alpha-1d adrenergic receptor antagonist
Higher selectivity for the alpha 1D subtype over the alpha 1A type (3-fold) and alpha 1B type (17-fold).
- Alpha-1a adrenergic receptorINHIBITOR
ADRA1A inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1- Mol. weight
- 392.5 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL142635 ↗
- ChEMBLCHEMBL1257069 ↗
Also known as
- 1-(4-(2-methoxyphenyl)-1-piperazinyl)-3-(1-naphthyloxy)-2-propanol
- avishot
- flivas
- naftopidil
- naftopidil
- naftopidil
- naftopidil
- naftopidil
- naftopidil
- naftopidil
- naftopidil
- naftopidil dihydrochloride
- naftopidil hcl
- naftopidil hydrochloride
- naftopil
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01952314 | Phase 3 | May 1, 2014 | Dong-A Pharmaceutical, Seoul National University |
| NCT01959074 | Phase 3 | May 1, 2014 | Dong-A Pharmaceutical, Seoul National University |
| NCT02011737 | Phase 4 | Feb 1, 2014 | Dong-A Pharmaceutical, Sungkyunkwan University |
| NCT02034604 | Phase 4 | Dec 1, 2013 | Sungkyunkwan University |
| NCT01922375 | Phase 4 | Dec 1, 2011 | Catholic University of Korea, Chonbuk National University, Dong-A Pharmaceutical, Ewha Womans University, Gyeongsang University, Hallym University, Inha University, Inje University, Korea University, Pusan National University, Seoul National University, Sungkyunkwan University, University of Ulsan, Yeongnam University |
| NCT01203371 | Phase 3 | Jan 1, 2011 | Apsen Farmaceutica S.A. |
| NCT00967772 | Phase 1 | Sep 1, 2009 | Dong-A Pharmaceutical, Seoul National University |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (15)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Dong-A Pharmaceutical | For profit | 5 | 2 | 3 | 2009 |
| Seoul National University | Academic/Hospital | 4 | 2 | 3 | 2009 |
| Sungkyunkwan University | Academic/Hospital | 3 | 2 | 1 | 2011 |
| Apsen Farmaceutica S.A. | For profit | 1 | 1 | 1 | 2011 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Chonbuk National University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Ewha Womans University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Gyeongsang University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Hallym University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Inha University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Inje University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Korea University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Pusan National University | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Ulsan | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Yeongnam University | Academic/Hospital | 1 | 0 | 1 | 2011 |
15 organizations
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