kynurenic acid
Kynurenic acid is a product of the normal metabolism of amino acid L-tryptophan. It has been shown that kynurenic acid possesses neuroactive activity. It acts as an antiexcitotoxic and anticonvulsant, most likely through acting as an antagonist at excitatory amino acid receptors. Because of this activity, it may influence important neurophysiological and neuropathological processes. As a result, kynurenic acid has been considered for use in therapy in certain neurobiological disorders. Conversely, increased levels of kynurenic acid have also been linked to certain pathological conditions. — Wikipedia
Clinical trial activity
3 trials · 5 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2015 (NCT02340325)
Timeline
Indications
Mechanism of action
- Glutamate NMDA receptorANTAGONIST
Glutamate NMDA receptor antagonist
- Glutamate receptor ionotropic, NMDA 2A (Grin2a) ↗
- Glutamate receptor ionotropic, NMDA 3B (Grin3b) ↗
- Glutamate receptor ionotropic, NMDA 2D (Grin2d) ↗
- Glutamate receptor ionotropic, NMDA 1 (Grin1) ↗
- Glutamate receptor ionotropic, NMDA 2B (Grin2b) ↗
- Glutamate receptor ionotropic, NMDA 2C (Grin2c) ↗
- Glutamate receptor ionotropic, NMDA3A (Grin3a) ↗
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaKynurenic acid ↗
Also known as
- kynurenic acid
- kynurenic acid
- kynurenic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06807021 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2025 | Birch BioMed Inc, Nutrasource Diagnostics |
| NCT04186273 | Phase 2 | Nov 25, 2019 | University of British Columbia |
| NCT02340325 | Phase 1 | May 1, 2015 | BC Professional Fire Fighters' Burn and Wound Healing Laboratory, British Columbia Professional Firefighters' Burn and Wound Healing Laboratory |
Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| BC Professional Fire Fighters' Burn and Wound Healing Laboratory | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Birch BioMed Inc | For profit | 1 | 1 | 1 | 2025 |
| British Columbia Professional Firefighters' Burn and Wound Healing Laboratory | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Nutrasource Diagnostics | For profit | 1 | 0 | 1 | 2025 |
| University of British Columbia | Academic/Hospital | 1 | 1 | 1 | 2019 |