methocarbamol
Trade name: robaxin
Approved
Jul 16, 1957
Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect. Methocarbamol is used for use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Under the trade name Robaxin, Methocarbamol is marketed by Actient Pharmaceuticals in the United States and Pfizer in Canada. — NCATS
Clinical trial activity
10 trials · 12 clinical orgs · 64 marketing orgs
Earliest trial started Nov 1, 2013 (NCT01979510)
Timeline
1950s
1970s
- Feb 25, 1974
Puracap Pharmaceutical — Marketing Organization
- May 16, 1975
Sun Pharmaceuticals — Marketing Organization
- Dec 19, 1975
Fosun — Marketing Organization
- Aug 11, 1976
Hikma — Marketing Organization
- Aug 20, 1976
Impax Laboratories — Marketing Organization
- Aug 20, 1976
Watson Pharmaceuticals — Marketing Organization
- Aug 25, 1976
Solvay — Marketing Organization
- Nov 23, 1976
Chartwell Pharmaceuticals — Marketing Organization
- Nov 23, 1976
Lannett Company, Inc. — Marketing Organization
- Jan 4, 1977
Ani Pharmaceuticals — Marketing Organization
- Aug 3, 1977
Ferndale Laboratories, Inc. — Marketing Organization
- Dec 19, 1977
Clonmel Hlthcare — Marketing Organization
- Oct 29, 1979
Prinston Inc — Marketing Organization
1980s
- Feb 19, 1980
Lumara Health — Marketing Organization
- Jul 3, 1980
Dr. Reddy's Laboratories — Marketing Organization
- Feb 3, 1982
Mylan — Marketing Organization
- Sep 22, 1982
Sandoz — Marketing Organization
- Dec 22, 1982
Teva — Marketing Organization
- Dec 17, 1984
Ascot Pharmaceuticals — Marketing Organization
- Feb 12, 1986
McNeil — Marketing Organization
- Feb 12, 1986
Johnson and Johnson — Marketing Organization
- Nov 4, 1988
Par Pharmaceuticals — Marketing Organization
1990s
- Dec 27, 1991
Marsam Pharmaceuticals — Marketing Organization
- Jan 31, 1995
Jerome Stevens Pharmaceuticals — Marketing Organization
2000s
- Jan 29, 2003
Oxford Pharmaceuticals — Marketing Organization
- Mar 17, 2003
Able Laboratories — Marketing Organization
- Nov 6, 2009
Hetero Labs Ltd — Marketing Organization
2010s
- Oct 21, 2011
Austarpharma — Marketing Organization
- Jan 1, 2013
Earliest Phase 3 Sponsor(trial)
- May 27, 2016
Aurobindo Pharma — Marketing Organization
- May 27, 2016
Eugia Pharma — Marketing Organization
- Oct 27, 2016
Monterey Pharmaceuticals — Marketing Organization
- Jan 19, 2017
Hainan Poly Pharm — Marketing Organization
- Jan 19, 2017
Slate Pharmaceuticals — Marketing Organization
- Jan 19, 2017
SLATE RUN PHARMA — Marketing Organization
- Feb 8, 2017
ACME Laboratories — Marketing Organization
- Feb 8, 2017
DBL Group — Marketing Organization
- Jun 22, 2017
Lutipold — Marketing Organization
- Jun 22, 2017
Sankyo — Marketing Organization
- Jun 22, 2017
Daiichi Sankyo — Marketing Organization
- Jul 18, 2017
Sagent Pharmaceuticals, Inc. — Marketing Organization
- Jul 18, 2017
Nichi-Iko Pharmaceutical Co., Ltd. — Marketing Organization
- Jul 21, 2017
Beximco — Marketing Organization
- Jul 31, 2017
Somerset Pharmaceuticals — Marketing Organization
- Nov 24, 2017
Navinta — Marketing Organization
- Apr 17, 2018
Fresenius — Marketing Organization
- May 7, 2018
Granules India — Marketing Organization
- Oct 26, 2018
Gland Pharma Ltd — Marketing Organization
2020s
- Apr 30, 2021
Granulation Tech — Marketing Organization
- Jul 14, 2022
Baxalta — Marketing Organization
- Jul 14, 2022
Takeda — Marketing Organization
- Jun 12, 2023
Mikart — Marketing Organization
- Jun 12, 2023
Nautic Partners — Marketing Organization
Indications
Approved for
Mechanism of action
- Carbonic anhydrase IINHIBITOR
CA1 inhibitor
Combination products
robaxisal
with acetylsalicylic acid
Approval history
- approvedJul 16, 1957
Chemistry & pharmacology
SMILES
COC1=CC=CC=C1OCC(O)COC(N)=O- Mol. weight
- 241.2405 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral, Parenteral
- Availability
- Prescription Only
Oral
Yes
Parenteral
Yes
Topical
No
Sources
- WikipediaMethocarbamol ↗
- NCATS125OD7737X ↗
- ChEMBLCHEMBL1201117 ↗
Also known as
- delaxin
- delaxin
- delaxin
- forbaxin
- forbaxin
- glycerylguaiacolate carbamate
- guaiacol glyceryl ether carbamate
- guaiamar carbamate
- guaiphenesin carbamate
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- methocarbamol
- méthocarbamol
- méthocarbamol
- methocarbamolum
- methocarbamolum
- metocarbamol
- metocarbamol
- metocarbamolo
- metocarbamolo
- miolaxin
- neuraxin
- neuraxin
- robaxin
- robaxin
- robaxin
- robaxin-750
- robaxin-750
- (rs)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
- (rs)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05603832 | Phase 3 | Nov 17, 2022 | Allucent, Arthritis Innovation Corporation |
| NCT05388929 | Phase 4 | Jun 23, 2022 | Prisma Health |
| NCT05076110 | Phase 4 | Dec 31, 2021 | Mayo Clinic |
| NCT05204667 | Phase 4 | Oct 7, 2021 | Angelini, Hippocrates Research |
| NCT05100017 | N/A | Sep 30, 2021 | Northwestern University |
| NCT02642874 | Phase 3 | Oct 1, 2016 | Tanta University |
| NCT02831569 | Phase 3 | Jul 1, 2016 | Boehringer Ingelheim |
| NCT02665286 | Phase 4 | Mar 1, 2016 | Yeshiva University |
| NCT02432456 | Phase 4 | Sep 1, 2015 | Medical College of Wisconsin |
| NCT01979510 | Phase 3 | Nov 1, 2013 | Merck |
Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Allucent | For profit | 1 | 0 | 1 | 2022 |
| Angelini | For profit | 1 | 1 | 1 | 2021 |
| Arthritis Innovation Corporation | For profit | 1 | 1 | 1 | 2022 |
| Boehringer Ingelheim | For profit | 1 | 1 | 1 | 2016 |
| Hippocrates Research | For profit | 1 | 0 | 1 | 2021 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Medical College of Wisconsin | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Merck | For profit | 1 | 1 | 1 | 2013 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Prisma Health | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Tanta University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Yeshiva University | Academic/Hospital | 1 | 1 | 1 | 2016 |
Marketing (73)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| ACME Laboratories | For profit | MKTG | Feb 8, 2017 |
| AH Robins | For profit | MKTG | Apr 15, 1960 |
| AH Robins | For profit | NDA2 | Apr 15, 1960 |
| Able Laboratories | For profit | MKTG | Mar 17, 2003 |
| Am Therap | For profit | MKTG | — |
| Ani Pharmaceuticals | For profit | MKTG | Jan 4, 1977 |
| Ani Pharmaceuticals | For profit | MKTG | Jan 4, 1977 |
| Ascot Pharmaceuticals | For profit | MKTG | Dec 17, 1984 |
| Aurobindo Pharma | For profit | MKTG | May 27, 2016 |
| Austarpharma | For profit | MKTG | Oct 21, 2011 |
| Auxillium | For profit | NDA | Jul 16, 1957 |
| Auxillium | For profit | NDA2 | Jul 16, 1957 |
| Baxalta | For profit | MKTG | Jul 14, 2022 |
| Beximco | For profit | MKTG | Jul 21, 2017 |
| Chartwell Pharmaceuticals | For profit | MKTG | Nov 23, 1976 |
| Clonmel Hlthcare | For profit | MKTG | Dec 19, 1977 |
| DBL Group | For profit | MKTG | Feb 8, 2017 |
| Daiichi Sankyo | For profit | MKTG | Jun 22, 2017 |
| Dow Chemical | For profit | MKTG | — |
| Dr. Reddy's Laboratories | For profit | MKTG | Jul 3, 1980 |
| Eugia Pharma | For profit | MKTG | May 27, 2016 |
| Ferndale Laboratories, Inc. | For profit | MKTG | Aug 3, 1977 |
| Forest Laboratories | For profit | MKTG | — |
| Fosun | For profit | MKTG | Dec 19, 1975 |
| Fresenius | For profit | MKTG | Apr 17, 2018 |
| Gland Pharma Ltd | For profit | MKTG | Oct 26, 2018 |
| Granulation Tech | For profit | MKTG | Apr 30, 2021 |
| Granules India | For profit | MKTG | May 7, 2018 |
| Granules India | For profit | SYN | May 7, 2018 |
| Hainan Poly Pharm | For profit | MKTG | Jan 19, 2017 |
| Heather Pharma | For profit | MKTG | — |
| Hetero Labs Ltd | For profit | MKTG | Nov 6, 2009 |
| Hikma | For profit | NDA2 | Jun 10, 1959 |
| Hikma | For profit | MKTG | Aug 11, 1976 |
| Hikma | For profit | SYN | Jun 10, 1959 |
| Impax Laboratories | For profit | MKTG | Aug 20, 1976 |
| Inwood Laboratories | For profit | MKTG | — |
| Jerome Stevens Pharmaceuticals | For profit | MKTG | Jan 31, 1995 |
| Johnson and Johnson | For profit | MKTG | Feb 12, 1986 |
| Lannett Company, Inc. | For profit | MKTG | Nov 23, 1976 |
| Lumara Health | For profit | MKTG | Feb 19, 1980 |
| Lutipold | For profit | MKTG | Jun 22, 2017 |
| Marsam Pharmaceuticals | For profit | MKTG | Dec 27, 1991 |
| McNeil | For profit | MKTG | Feb 12, 1986 |
| Mikart | For profit | MKTG | Jun 12, 2023 |
| Monterey Pharmaceuticals | For profit | MKTG | Oct 27, 2016 |
| Mylan | For profit | MKTG | Feb 3, 1982 |
| Mylan | For profit | SYN | Dec 5, 2014 |
| Mylan | For profit | SYN | Apr 30, 2021 |
| NYLOS | For profit | MKTG | — |
| Nautic Partners | For profit | MKTG | Jun 12, 2023 |
| Navinta | For profit | MKTG | Nov 24, 2017 |
| Nichi-Iko Pharmaceutical Co., Ltd. | For profit | MKTG | Jul 18, 2017 |
| Oxford Pharmaceuticals | For profit | MKTG | Jan 29, 2003 |
| Par Pharmaceuticals | For profit | MKTG | Nov 4, 1988 |
| Prinston Inc | For profit | MKTG | Oct 29, 1979 |
| Puracap Pharmaceutical | For profit | MKTG | Feb 25, 1974 |
| Roxane Laboratories | For profit | MKTG | — |
| SLATE RUN PHARMA | For profit | MKTG | Jan 19, 2017 |
| Sagent Pharmaceuticals, Inc. | For profit | MKTG | Jul 18, 2017 |
| Sagent Pharmaceuticals, Inc. | For profit | SYN | Jul 18, 2017 |
| Sandoz | For profit | MKTG | Sep 22, 1982 |
| Sankyo | For profit | MKTG | Jun 22, 2017 |
| Slate Pharmaceuticals | For profit | MKTG | Jan 19, 2017 |
| Solvay | For profit | MKTG | Aug 25, 1976 |
| Somerset Pharmaceuticals | For profit | MKTG | Jul 31, 2017 |
| Sun Pharmaceuticals | For profit | MKTG | May 16, 1975 |
| Superpharm | For profit | MKTG | — |
| Tablicaps | For profit | MKTG | — |
| Takeda | For profit | MKTG | Jul 14, 2022 |
| Teva | For profit | MKTG | Dec 22, 1982 |
| Upsher-Smith Laboratories | For profit | MKTG | — |
| Watson Pharmaceuticals | For profit | MKTG | Aug 20, 1976 |